Evidence map›Paper›PMID 39312076›Full record

ArticleMolecular biology reports2024

N-acetylcysteine mitigates oxidative damage to the ovary in D-galactose-induced ovarian failure in rabbits.

Yu Xue, Huafeng Bian, Shaocheng Bai, Zhiyuan Bao, Lei Wang, Sen Wang, Bohao Zhao, Xinsheng Wu, Yang Chen

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yu Xue *College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.ORCID https://orcid.org/0009-0001-3691-2509
Huafeng Bian *College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.ORCID https://orcid.org/0009-0002-9132-6155
Shaocheng BaiCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.ORCID https://orcid.org/0000-0002-6078-4252
Zhiyuan BaoCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.ORCID https://orcid.org/0000-0002-4548-0920
Lei WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.ORCID https://orcid.org/0009-0000-5265-7811
Sen WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.ORCID https://orcid.org/0009-0008-9562-3900
Bohao ZhaoCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.ORCID https://orcid.org/0000-0003-3333-1001
Xinsheng WuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.ORCID https://orcid.org/0000-0001-9871-0251
Yang ChenCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China. yangc@yzu.edu.cn.ORCID https://orcid.org/0000-0001-9097-5132

Funding

China Agriculture Research System of MOF and MARA CARS-43-A-1Qing Lan Project of Yangzhou university 2022
6 · The paper itself

Abstract

backgroundOxidative damage to the ovaries is the primary cause of impaired reproductive functions in female animals. This study aimed to investigate the protective role of N-Acetyl-L-cysteine (NAC) in reducing oxidative damage in the ovaries of female rabbits. METHODS AND

resultsFemale rabbit ovaries were treated in vitro with varying concentrations of D-galactose (D-gal): 0, 5, 10, and 15 mg/mL, and it was found that 10 mg/mL D-gal significantly disrupted follicular structures, causing disarray in granulosa cell arrangements and significantly reducing T-SOD and GSH levels (p < 0.01). Consequently, we selected 10 mg/mL D-gal to establish an ovarian failure model. These models were treated with multiple doses of NAC (0, 0.1, 0.3, 0.5 mg/mL). The results revealed that the disruption in granulosa cell arrangement caused by 10 mg/mL D-gal was effectively alleviated by 0.1 mg/mL NAC compared to the D-gal treatment group. Furthermore, 10 mg/mL D-gal significantly (p < 0.01) reduced GSH, T-SOD, and catalase (CAT) levels in the ovaries. However, 0.1 mg/mL NAC effectively (p < 0.01) suppressed these adverse effects. Moreover, the current results showed that 10 mg/mL D-gal alone significantly (p < 0.01) downregulated the expression of Nrf2, GPX, PRDX4, GSR, SOD1, and TAF4B, whereas 0.1 mg/mL NAC counteracted these suppressive effects (p < 0.01).

conclusionsIt could be concluded that NAC may delay ovarian failure by reducing D-gal-induced ovarian oxidative damage in female rabbit, suggested NAC could be a promising therapeutic agent for protecting against ovarian failure and potentially delaying ovarian failure in female rabbits.

Indexed as

AcetylcysteineGalactoseOvaryOxidative StressAnimalsAntioxidantsCatalaseDisease Models, AnimalFemaleGlutathioneGranulosa CellsPrimary Ovarian InsufficiencyRabbitsSuperoxide DismutaseAcetylcysteineAntioxidantsCatalaseGalactoseGlutathioneSuperoxide DismutaseD-galactoseN-acetylcysteineOvarian failureOxidative damage

Identifiers

PMID39312076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.