Evidence map›Paper›PMID 39312069›Full record

ArticleMolecular neurobiology2025

TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus.

Xiuting Qi, Xi Chen, Qi Luo, Lihan Liu, Dong An, Sha Sha, Yimei Du, Chunfeng Wu, Lei Chen

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiuting QiDepartment of Physiology, Nanjing Medical University, Jiangsu Province, Nanjing, 211166, People's Republic of China.
Xi ChenDepartment of Physiology, Nanjing Medical University, Jiangsu Province, Nanjing, 211166, People's Republic of China.
Qi LuoDepartment of Physiology, Nanjing Medical University, Jiangsu Province, Nanjing, 211166, People's Republic of China.
Lihan LiuDepartment of Physiology, Nanjing Medical University, Jiangsu Province, Nanjing, 211166, People's Republic of China.
Dong AnCenter for Analysis and Testing, Nanjing Medical University, Jiangsu Province, Nanjing, 211166, People's Republic of China.
Sha ShaDepartment of Physiology, Nanjing Medical University, Jiangsu Province, Nanjing, 211166, People's Republic of China.
Yimei DuResearch Center of Ion Channelopathy, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan, 430022, People's Republic of China.
Chunfeng WuDepartment of Neurology, Children's Hospital of Nanjing Medical University, No.8, Jiangdong South Road, Jiangsu Province, Nanjing, 210008, People's Republic of China. wcf1108@njmu.edu.cn.ORCID http://orcid.org/0009-0007-9967-8987
Lei ChenDepartment of Physiology, Nanjing Medical University, Jiangsu Province, Nanjing, 211166, People's Republic of China. chenl@njmu.edu.cn.ORCID http://orcid.org/0000-0002-7382-8306

Funding

National Natural Science Foundation of China 81971274National Natural Science Foundation of China 82170326
6 · The paper itself

Abstract

Aberrant neurogenesis in the adult hippocampal dentate gyrus (DG) contributes to synapse remodeling during temporal lobe epilepsy (TLE). Transient receptor potential vanilloid 4 (TRPV4) is involved in the pathogenesis of TLE. Activation of TRPV4 can modulate neurogenesis in the adult hippocampal DG. The present study examined whether TRPV4 is responsible for the aberrant neurogenesis in the adult hippocampal DG during TLE. Herein, administration of a TRPV4-specific antagonist, HC-067047, attenuated the enhanced neural stem cell proliferation in the adult hippocampal DG in mice following pilocarpine‑induced status epilepticus (PISE). HC-067047 reduced the heightened hippocampal protein levels of cyclin-dependent kinase (CDK) 2, CDK6, cyclin E1, cyclin A2, and phosphorylated retinoblastoma (p-Rb) observed following PISE. Meanwhile, HC-067047 inhibited the extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38 MAPK) pathways that were enhanced and responsible for the increased proliferation of stem cells and higher levels of CDKs, cyclins, and p-Rb protein. HC-067047 reduced the 28-day-old BrdU

Indexed as

Dentate GyrusNeurogenesisStatus EpilepticusTRPV Cation ChannelsAgingAnimalsCell ProliferationMaleMiceMice, Inbred ICRMorpholinesNeural Stem CellsPilocarpinePyrrolesSignal TransductionHC-067047MorpholinesPilocarpinePyrrolesTrpv4 protein, mouseTRPV Cation ChannelsHippocampal dentate gyrusMitogen-activated protein kinaseNeurogenesisProtein kinase BTemporal lobe epilepsyTransient receptor potential vanilloid 4

Identifiers

PMID39312069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.