Evidence map›Paper›PMID 39312029›Full record

ArticleMolecular and cellular biochemistry2025

BsmI, ApaI and FokI variants of vitamin D receptor gene polymorphism as predictors of response to treatment in immune thrombocytopenia patients.

Rania A Radwan, Walaa A Elsalakawy, Doaa M Abdelaziz, Doaa M Abdelrazek, Sara M Radwan

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Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Vitamin D Receptor rs7975232 (Journal of clinical medicine · 2025
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Rania A RadwanInternal Medicine, Clinical Hematology and Bone Marrow Transplantation Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Walaa A ElsalakawyInternal Medicine, Clinical Hematology and Bone Marrow Transplantation Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Doaa M AbdelazizClinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Doaa M AbdelrazekClinical Hematology Department, Faculty of Medicine, Ain Shams University, Cairo, 11566, Egypt.
Sara M RadwanBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. sara.mostafa@pharma.asu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D receptor (VDR) polymorphisms are linked with the incidence and severity of several autoimmune diseases. The current work aimed at evaluating if VDR rs1544410 (BsmI), rs7975232 (ApaI) and rs2228570 (FokI) gene polymorphisms could be predictors of response to steroid treatment in patients with immune thrombocytopenia (ITP). The study involved 75 steroid treatment responders and 75 resistant ITP patients. All participants were subjected to VDR BsmI, ApaI and FokI gene polymorphisms analysis through genotyping by RT-PCR. Carrying the FokI F allele was significantly associated with low vitamin D level and increased risk of developing steroid resistance. Interestingly, the tri-allelic haplotypes BAF and BaF were significantly only present in steroid resistant ITP patients. Thus, the present study suggests that VDR FokI F allele may contribute to ITP pathogenesis and resistance to steroid treatment. Knowing the genetic background of patients helps to individualize treatment to obtain a better outcome.

Indexed as

Polymorphism, Single NucleotidePurpura, Thrombocytopenic, IdiopathicReceptors, CalcitriolAdultAgedAllelesFemaleHumansMaleMiddle AgedReceptors, CalcitriolVDR protein, humanApaIBsmIFokIImmune thrombocytopeniaVitamin D receptor polymorphism

Identifiers

PMID39312029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.