Evidence map›Paper›PMID 39311876›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

Distinct Responses of Cystic Fibrosis Epithelial Cells to SARS-CoV-2 and Influenza A Virus.

Isabel Pagani, Arianna Venturini, Valeria Capurro, Alessandro Nonis, Silvia Ghezzi, Mariateresa Lena, Beatriz Alcalá-Franco, Fabrizio Gianferro, Daniela Guidone, Carla Colombo and 5 more

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Antiviral defenses are diminished at birth in cystic fibrosis pig airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Isabel PaganiViral Pathogenesis and Biosafety Unit and.
Arianna VenturiniTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.
Valeria CapurroUnit of Medical Genetics (UOC), IRCCS Giannina Gaslini Institute, Genoa, Italy.
Alessandro NonisUniversity Centre for Statistics in the Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University, Milan, Italy.
Silvia GhezziViral Pathogenesis and Biosafety Unit and.
Mariateresa LenaUnit of Medical Genetics (UOC), IRCCS Giannina Gaslini Institute, Genoa, Italy.
Beatriz Alcalá-FrancoInfections and Cystic Fibrosis Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Fabrizio GianferroInfections and Cystic Fibrosis Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Daniela GuidoneTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.
Carla ColomboFoundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Nicoletta PedemonteUnit of Medical Genetics (UOC), IRCCS Giannina Gaslini Institute, Genoa, Italy.
Alessandra BragonziInfections and Cystic Fibrosis Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cristina CiganaInfections and Cystic Fibrosis Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Luis J V GaliettaTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.
Elisa VicenziViral Pathogenesis and Biosafety Unit and.

Funding

Cystic Fibrosis Foundation 00160G220Italian Ministry of Health RF-COVID-2020-12371781
6 · The paper itself

Abstract

The coronavirus disease (COVID-19) pandemic has underscored the impact of viral infections on individuals with cystic fibrosis (CF). Initial observations suggested lower COVID-19 rates among CF populations; however, subsequent clinical data have presented a more complex scenario. This study aimed to investigate how bronchial epithelial cells from individuals with and without CF, including various

Indexed as

COVID-19Cystic FibrosisEpithelial CellsInfluenza A virusInfluenza, HumanSARS-CoV-2Angiotensin-Converting Enzyme 2BronchiCystic Fibrosis Transmembrane Conductance RegulatorHumansMaleMutationVirus ReplicationACE2 protein, humanAngiotensin-Converting Enzyme 2CFTR protein, humanCystic Fibrosis Transmembrane Conductance Regulatorbronchial epithelial cellscystic fibrosis mutationscytokine and chemokine responseinfluenza A virusSARS-CoV-2 variants

Identifiers

PMID39311876
PMCPMC11890075

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.