Evidence map›Paper›PMID 39311765›Full record

ArticleJournal of medicinal chemistry2024

Computationally Driven Discovery of a BCR-ABL1 Kinase Inhibitor with Activity in Multidrug-Resistant Chronic Myeloid Leukemia.

Jarvis Hill, R Houston Givhan, Bin Yi, Robert M Jones, Eugene F Douglass, Yaguang Xi, Henry F Schaefer, David Crich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Intramolecular N-O Bond Formation for the Synthesis ofJournal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jarvis HillDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.ORCID 0000-0003-2251-5569
R Houston GivhanDepartment of Chemistry, University of Georgia, 302 East Campus Road, Athens, Georgia 30602, United States.
Bin YiDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.
Robert M JonesIndependent consultant, P.O. Box 568, Oakley, Utah 84055-0568, United States.
Eugene F DouglassDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.
Yaguang XiDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.
Henry F SchaeferDepartment of Chemistry, University of Georgia, 302 East Campus Road, Athens, Georgia 30602, United States.ORCID 0000-0003-0252-2083
David CrichDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.ORCID 0000-0003-2400-0083

Funding

Sulindac sensitizes colorectal cancer to anti-PD-L1 therapyR01CA271533 · NCI · UNIVERSITY OF GEORGIA · PI Yaguang Xi · 2022 to 2026
$2.2M
Investigate interactive roles of environmental, behavioral and genetic factors on racial disparities in breast cancer outcomesR01CA260698 · NCI · UNIVERSITY OF GEORGIA · PI XI, YAGUANG · 2021 to 2025
$2.0M
NCI NIH HHS R01 CA260698NCI NIH HHS R01 CA271533
6 · The paper itself

Abstract

The permeability glycoprotein, encoded by the

Indexed as

Drug Resistance, NeoplasmFusion Proteins, bcr-ablLeukemia, Myelogenous, Chronic, BCR-ABL PositiveProtein Kinase InhibitorsProto-Oncogene MasAntineoplastic AgentsDrug DiscoveryDrug Resistance, MultipleHumansMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsBCR-ABL1 fusion protein, humanFusion Proteins, bcr-ablMAS1 protein, humanProtein Kinase InhibitorsProto-Oncogene Mas

Identifiers

PMID39311765
PMCPMC11472320

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.