Evidence map›Paper›PMID 39311502›Full record

Trial reportDiabetes & vascular disease research

Five-year outcomes of patients with diabetes mellitus treated with a sirolimus-eluting or a biolimus-eluting stents with biodegradable polymer. From the SORT OUT VII trial.

Jens Trøan, Evald Høj Christiansen, Kirstine Nørregaard Hansen, Ashkan Eftekhari, Lars Jakobsen, Michael Mæng, Phillip Freeman, Rebekka Vibjerg Jensen, Martin Kirk Christensen, Manijeh Noori and 5 more

Registry-linked trialAbstract readRandomized Controlled TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01879358 (Randomized Comparison of a Sirolimus Eluting ORSIRO Stent With a Biolimus-eluting NOBORI Stent in Patients Treated With Percutaneous Coronary Intervention), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01879358 naunknown statusnot on this map

Randomized Comparison of a Sirolimus Eluting ORSIRO Stent With a Biolimus-eluting NOBORI Stent in Patients Treated With Percutaneous Coronary Intervention

TypeinterventionalSponsorOdense University HospitalRan2012 to 2021Enrolled2,314ConditionsCoronary Artery Disease, Ischemic Heart DiseaseArmsDrug-eluting stent
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jens TrøanDepartment of Cardiology, Odense University Hospital, Odense, Denmark.ORCID 0000-0002-0929-8697
Evald Høj ChristiansenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Kirstine Nørregaard HansenDepartment of Cardiology, Odense University Hospital, Odense, Denmark.
Ashkan EftekhariDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Lars JakobsenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Michael MængDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Phillip FreemanDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Rebekka Vibjerg JensenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Martin Kirk ChristensenDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Manijeh NooriDepartment of Cardiology, Odense University Hospital, Odense, Denmark.
Julia Ellert-GregersenDepartment of Cardiology, Odense University Hospital, Odense, Denmark.
Nicolaj Brejnholt StøttrupDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Johnny KahlertDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
Karsten Tange VeienDepartment of Cardiology, Odense University Hospital, Odense, Denmark.
Lisette Okkels JensenDepartment of Cardiology, Odense University Hospital, Odense, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes mellitus is associated with higher risk of target lesion failure (TLF) after percutaneous coronary intervention. We studied the 5-year outcome in patients with diabetes mellitus treated with biodegradable polymer stents.

methodsThe SORT OUT VII was a randomised trial comparing the ultrathin sirolimus-eluting Orsiro stent (O-SES) and the biolimus-eluting Nobori stent (N-BES) in an all-comer setting. Patients (

resultsPatients with diabetes mellitus had higher TLF (20.6% vs 11.0%, (Rate ratio (RR) 1.85 95% confidence interval (CI): (1.42-2.40) and patient related outcome (42.0% vs 31.0%, RR 1.43 95% CI: (1.19-1.71)) compared to patients without diabetes. Among patients with diabetes mellitus, TLF after 5 years did not differ between O-SES and N-BES (21.2% vs 20.0%), RR 1.05 95% CI: (0.70-1.58),

conclusionIn patients with diabetes mellitus, 5-year outcomes were similar among patients treated with biodegradable polymer O-SES or N-BES. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01879358.

Indexed as

Absorbable ImplantsCardiovascular AgentsCoronary Artery DiseaseDiabetes MellitusDrug-Eluting StentsPercutaneous Coronary InterventionProsthesis DesignSirolimusAgedCoronary ThrombosisFemaleHumansMaleMiddle AgedMyocardial InfarctionPolymersCardiovascular AgentsPolymersSirolimusumirolimusbiodegradable polymerdiabetes mellitusDrug-eluting stenttarget lesion failure

Identifiers

PMID39311502
PMCPMC11450620

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.