Evidence map›Paper›PMID 39311310›Full record

ArticlePathophysiology : the official journal of the International Society for Pathophysiology2024

Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient.

Gokhan Yilmaz, Jonathan Steven Alexander

Abstract read
In one paragraph

Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gokhan YilmazMolecular Cellular and Biomedical Sciences, CUNY School of Medicine, New York, NY 10031, USA.ORCID 0000-0003-4892-0984
Jonathan Steven AlexanderMolecular & Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA.ORCID 0000-0001-6975-3711

Funding

PSC CUNY Cycle 54 Award, CUNY Start-up funds. 66608-00 54
6 · The paper itself

Abstract

High systolic blood pressure and increased blood pressure variability after the onset of ischemic stroke are associated with poor clinical outcomes. One of the key determinants of blood pressure is arteriolar size, determined by vascular smooth muscle tone and vasodilatory and vasoconstrictor substances that are released by the endothelium. The aim of this study is to outline alterations in vasomotor function in isolated peripheral arteries following ischemic stroke. The reactivity of thoracic aortic segments from male C57BL/6 mice to dilators and constrictors was quantified using wire myography. Acetylcholine-induced endothelium-dependent vasodilation was impaired after ischemic stroke (LogIC50 Sham = -7.499, LogIC50 Stroke = -7.350,

Indexed as

alpha-adrenergic receptorsblood pressurehypertensionhypotensionischemic strokemiddle cerebral artery occlusionmyographyperipheral vesselsvasoconstrictionvasodilation

Identifiers

PMID39311310
PMCPMC11417821

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.