ArticleAdvances in respiratory medicine2024
Small Airways Dysfunction and Lung Hyperinflation in Long COVID-19 Patients as Potential Mechanisms of Persistent Dyspnoea.
Article in Advances in respiratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Early alteration of single-breath nitrogen washout (ΔN₂/L) in smokers with preserved spirometry: Association with smoking burden.Multidisciplinary respiratory medicine · 2026Article
- Imaging biomarkers of post-COVID dyspnea: insights from machine learning CT patterns and parametric response mapping.Respiratory research · 2026Article
- Interpretable machine learning for predicting low-dose methylprednisolone effectiveness in long COVID.iScience · 2026Article
- Longitudinal functional lung imaging in children with Post-COVID-19 syndrome.Molecular and cellular pediatrics · 2026Article
- A Retrospective Observational Study of Pulmonary Impairments in Long COVID Patients.Biomedicines · 2026Article
- Longitudinal assessment of physiological and mental health changes following acute COVID-19 in Uganda.Communications health · 2026Article
- Small airway disease as a key factor in COPD: new perspectives and insights.Frontiers in medicine · 2025Review
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14 authors.
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Abstract
backgroundReticulation, ground glass opacities and post-infection bronchiectasis are present three months following hospitalisation in patients recovering from SARS-CoV-2 infection and are associated with the severity of acute infection. However, scarce data exist on small airways impairment and lung hyperinflation in patients with long COVID-19.
aimTo evaluate small airways function and lung hyperinflation in previously hospitalised patients with long COVID-19 and their association with post-COVID-19 breathlessness.
methodsIn total, 33 patients (mean ± SD, 53 ± 11 years) with long COVID-19 were recruited 149 ± 90 days following hospital discharge. Pulmonary function tests were performed and lung hyperinflation was defined as RV/TLC ≥ 40%. Small airways function was evaluated by measuring the closing volume (CV) and closing capacity (CC) using the single-breath nitrogen washout technique (SBN
resultsCC was 115 ± 28% pred. and open capacity (OC) was 90 ± 19. CC was abnormal in 13 patients (39%), CV in 2 patients (6.1%) and OC in 9 patients (27%). Lung hyperinflation was present in 15 patients, whilst the mean mMRC score was 2.2 ± 1.0. Lung hyperinflation was associated with CC (r = 0.772,
conclusionsLong COVID-19 patients present with small airways dysfunction and lung hyperinflation, which is associated with persistent dyspnoea, following hospitalisation.
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