Evidence map›Paper›PMID 39310813›Full record

ArticleF1000Research2024

In silico analysis of molecular mimicry between human aquaporin 3,

Andrés Sánchez, Yaquelin Padilla, Adriana Lorduy, Jorge Sanchez, Marlon Munera, Claudia Baena, Carlos Bernal, Juan Urrego

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In one paragraph

Article in F1000Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrés SánchezGroup of Research Medicine (GINUMED), Rafael Nunez University Corporation, Cartagena, Bolívar, Colombia.ORCID https://orcid.org/0000-0001-7460-3427
Yaquelin PadillaResearch Group of Pharmaceutical, Cosmetic, and Food Technology (GITFCA), University of Cartagena, Cartagena, Bolívar, Colombia.
Adriana LorduyResearch Group of Pharmaceutical, Cosmetic, and Food Technology (GITFCA), University of Cartagena, Cartagena, Bolívar, Colombia.
Jorge SanchezClinical and Experimental Allergy Group (GACE), University of Antioquia, Medellín, Antioquia, Colombia.
Marlon MuneraGroup of Research Medicine (GINUMED), Rafael Nunez University Corporation, Cartagena, Bolívar, Colombia.ORCID https://orcid.org/0000-0003-3428-0541
Claudia BaenaResearch Group of Pharmaceutical, Cosmetic, and Food Technology (GITFCA), University of Cartagena, Cartagena, Bolívar, Colombia.ORCID https://orcid.org/0000-0001-7196-2694
Carlos BernalResearch Group of Pharmaceutical, Cosmetic, and Food Technology (GITFCA), University of Cartagena, Cartagena, Bolívar, Colombia.ORCID https://orcid.org/0000-0001-8681-5777
Juan UrregoResearch Group of Pharmaceutical, Cosmetic, and Food Technology (GITFCA), University of Cartagena, Cartagena, Bolívar, Colombia.ORCID https://orcid.org/0000-0002-1388-8227

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition that has a significant impact on quality of life. The immune response and allergy symptoms in AD are triggered by the recognition of specific allergens by IgE antibodies. Cross-reactivity can lead to auto-IgE responses, potentially worsening AD symptoms. Our research aimed to enhance our understanding of allergenic sources, including A. fumigatus, and their role in AD. We focused on molecular mimicry between human AQP3 and A. fumigatus aquaporin. Methods: In our in-silico analysis, we compared the amino acid sequences of human aquaporin 3 (AQP3) and A. fumigatus aquaporin with 25 aquaporins from various allergenic sources, sourced from the UniProt and NCBI databases. Phylogenetic relationship analysis and homology-based modeling were conducted. We identified conserved antigenic regions located within the 3D structures. Results: The global identity levels among the studied aquaporins averaged 32.6%. One antigenic site exhibited a remarkable local region, with a conserved identity of 71.4%. We categorized the aquaporins into five monophyletic clades (A-E), with group B showing the highest identity (95%), including six mammalian aquaporins, including AQP3. When comparing Conclusions: We identified potential linear and conformational epitopes of AQP3, indicating a possible molecular mimicry between humans and

Indexed as

Aquaporin 3AquaporinsAspergillus fumigatusComputer SimulationMolecular MimicryPhylogenyAllergensAmino Acid SequenceFungal ProteinsHumansHypersensitivityModels, MolecularAllergensAQP3 protein, humanAquaporin 3AquaporinsFungal Proteinsaquaporins.Aspergillus fumigatusAtopic dermatitisin silicomolecular mimicry

Identifiers

PMID39310813
PMCPMC11415755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.