Evidence map›Paper›PMID 39310750›Full record

ArticleiScience2024

Defects in NK cell immunity of pediatric cancer patients revealed by deep immune profiling.

Eleni Syrimi, Naeem Khan, Paul Murray, Carrie Willcox, Tracey Haigh, Benjamin Willcox, Navta Masand, Claire Bowen, Danai B Dimakou, Jianmin Zuo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tumor Signatures of Physical Fitness: Insights from a Preclinical Model.Medicine and science in sports and exercise · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eleni SyrimiInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Naeem KhanInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Paul MurrayInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Carrie WillcoxInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Tracey HaighInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Benjamin WillcoxInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Navta MasandInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Claire BowenPathology department, Birmingham Children's Hospital, Birmingham, UK.
Danai B DimakouClinical Immunology Service, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Jianmin ZuoInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Sierra M BaroneDepartment of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Jonathan M IrishDepartment of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Pamela KearnsCancer Research UK Clinical Trials Unit, National Institute for Health Research Birmingham Biomedical Research Centre, Birmingham, UK.
Graham S TaylorInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Funding

Single Cell Methods for Bioeffector Discovery and AnalysisR01CA226833 · NCI · VANDERBILT UNIVERSITY · PI BRIAN O BACHMANN, Jonathan Michael Irish · 2019 to 2026
$6.1M
NCI NIH HHS R01 CA226833
6 · The paper itself

Abstract

Systemic immunity plays an important role in cancer immune surveillance and response to therapy, but little is known about the immune status of children with solid cancers. We performed a high-dimensional single-cell analysis of systemic immunity in 50 treatment-naive pediatric cancer patients, comparing them to age-matched healthy children. Children with cancer had a lower frequency of peripheral NK cells, which was not due to tumor sequestration, had lower surface levels of activating receptors and increased levels of the inhibitory NKG2A receptor. Furthermore, the natural killer (NK) cells of pediatric cancer patients were less mature and less cytotoxic when tested

Indexed as

CancerHealth sciencesImmunologyPediatrics

Identifiers

PMID39310750
PMCPMC11416690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.