Evidence map›Paper›PMID 39310722›Full record

ArticleEuropean heart journal open2024

Epicardial adipose tissue and muscle distribution affect outcomes in very old patients after transcatheter aortic valve replacement.

Susanne Rohrbach, Oezge Uluocak, Marieke Junge, Fabienne Knapp, Rainer Schulz, Andreas Böning, Holger M Nef, Gabriele A Krombach, Bernd Niemann

Abstract read
In one paragraph

Article in European heart journal open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Susanne RohrbachInstitute of Physiology, Justus Liebig University Giessen, Aulweg 129, 35392 Giessen, Germany.ORCID https://orcid.org/0000-0002-7523-5221
Oezge UluocakDepartment of Cardiac and Vascular Surgery, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Rudolph-Buchheim-Strasse 7, 35392 Giessen, Germany.
Marieke JungeDepartment of Cardiac and Vascular Surgery, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Rudolph-Buchheim-Strasse 7, 35392 Giessen, Germany.
Fabienne KnappInstitute of Physiology, Justus Liebig University Giessen, Aulweg 129, 35392 Giessen, Germany.
Rainer SchulzInstitute of Physiology, Justus Liebig University Giessen, Aulweg 129, 35392 Giessen, Germany.ORCID https://orcid.org/0000-0002-4066-4624
Andreas BöningDepartment of Cardiac and Vascular Surgery, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Rudolph-Buchheim-Strasse 7, 35392 Giessen, Germany.ORCID https://orcid.org/0000-0002-4404-510X
Holger M NefDepartment of Cardiology, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Klinikstrasse 33, 35392 Giessen, Germany.
Gabriele A KrombachDepartment of Radiology, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Klinikstrasse 33, 35392 Giessen, Germany.
Bernd NiemannDepartment of Cardiac and Vascular Surgery, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Rudolph-Buchheim-Strasse 7, 35392 Giessen, Germany.ORCID https://orcid.org/0000-0003-4431-7002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To analyse the relevance of body composition and blood markers for long-term outcomes in very old patients after transcatheter aortic valve replacement (TAVR). Methods and results: A total of 403 very old patients were characterized with regard to subcutaneous, visceral, and epicardial fat, psoas muscle area, plasma growth differentiation factor 15 (GDF-15), and leptin. Cohorts grouped by body mass index (BMI) were analysed for long-term outcomes. Patients underwent transapical and transfemoral TAVR (similar 30-day/1-year survival). Body mass index >35 kg/m Conclusion: Morbidly visceral and epicardial fat accumulation, reduction in muscle area, and GDF-15 increase are strong predictors of adverse outcomes in very old patients post-TAVR.

Indexed as

BMIEpicardial fatGDF-15Sarcopenic obesityTAVR

Identifiers

PMID39310722
PMCPMC11414403

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.