Evidence map›Paper›PMID 39310365›Full record

ArticleAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2024

Long-Term Follow-Up of Patients with Advanced Colorectal Liver Metastasis: A Survival Analysis from the Randomized Controlled Multicenter Trial LIGRO.

Dennis Björk, Kristina Hasselgren, Bård I Røsok, Peter N Larsen, Ernesto Sparrelid, Gert Lindell, Nicolai A Schultz, Bjorn A Bjørnbeth, Bengt Isaksson, Anna Lindhoff Larsson and 3 more

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In one paragraph

Article in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dennis BjörkFrom the Department of Surgery in Linköping and Institution for Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Kristina HasselgrenFrom the Department of Surgery in Linköping and Institution for Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Bård I RøsokDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
Peter N LarsenDepartment of Surgical Gastroenterology and Transplantation, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ernesto SparrelidDivision of Surgery and Oncology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Gert LindellDepartment of Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
Nicolai A SchultzDepartment of Surgical Gastroenterology and Transplantation, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Bjorn A BjørnbethDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
Bengt IsakssonDepartment of Surgery, Akademiska University Hospital, Uppsala, Sweden.
Anna Lindhoff LarssonFrom the Department of Surgery in Linköping and Institution for Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Magnus RizellDepartment of Transplantation and Liver Surgery, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bergthor BjörnssonFrom the Department of Surgery in Linköping and Institution for Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Per SandströmFrom the Department of Surgery in Linköping and Institution for Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The objective of this study was to evaluate the long-term oncological outcomes of patients with colorectal liver metastasis (CRLM) randomized for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) or 2-stage hepatectomy (TSH). Introduction: For advanced CRLM, TSH or ALPPS may be needed for tumor freedom. The randomized, controlled, multicenter trial LIGRO showed an increased resection rate in patients who underwent ALPPS but no difference in morbidity or mortality. The 2-year survival analysis revealed better overall survival in the ALPPS group. Here, the long-term survival analysis from the LIGRO trial is reported. Methods: In the LIGRO trial, 100 patients were randomized to TSH or ALPPS, with the option of rescue ALPPS if insufficient growth was found after the initial step of TSH. Patients were enrolled between June 2014 and August 2016. Follow-up data for this study were collected between November 2022 and February 2023. Results: In total, 16 patients were alive at the end of the follow-up period. The estimated median follow-up time was 93 months. Estimated median overall survival times were 45 months in the ALPPS group and 27 months in the TSH group ( Conclusion: Liver tumor-free status is a predictor of long-term survival, along with extrahepatic disease, large CRLM size, and rectal primary tumor. Survival did not significantly differ between patients treated with ALPPS or TSH.

Identifiers

PMID39310365
PMCPMC11415122

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.