Evidence map›Paper›PMID 39310046›Full record

ArticleBioinformatics advances2024

Making proteomics accessible: RokaiXplorer for interactive analysis of phospho-proteomic data.

Serhan Yılmaz, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Marzieh Ayati, Mark R Chance, Mehmet Koyutürk

Abstract read
In one paragraph

Article in Bioinformatics advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Serhan YılmazDepartment of Computer and Data Sciences, Case Western Reserve University, Cleveland, OH, 44106, United States.ORCID https://orcid.org/0000-0003-4669-9593
Filipa Blasco Tavares Pereira LopesDepartment of Nutrition, Case Western Reserve University, Cleveland, OH, 44106, United States.
Daniela SchlatzerDepartment of Nutrition, Case Western Reserve University, Cleveland, OH, 44106, United States.
Marzieh AyatiDepartment of Computer Science, University of Texas Rio Grande Valley, Edinburg, TX 78701, United States.ORCID https://orcid.org/0000-0002-5280-5738
Mark R ChanceDepartment of Nutrition, Case Western Reserve University, Cleveland, OH, 44106, United States.
Mehmet KoyutürkDepartment of Computer and Data Sciences, Case Western Reserve University, Cleveland, OH, 44106, United States.

Funding

Construction, Analysis, and Utilization of Co-Phosphorylation Networks to Characterize Cellular SignalingR01LM012980 · NLM · CASE WESTERN RESERVE UNIVERSITY · PI Marzieh Ayati, MARK R CHANCE · 2019 to 2026
$2.1M
Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer (QE HF-X)S10OD028614 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CHANCE, MARK R · 2020 to 2020
$600k
NIH HHS S10 OD028614NLM NIH HHS R01 LM012980
6 · The paper itself

Abstract

Summary: We present RokaiXplorer, an intuitive web tool designed to address the scarcity of user-friendly solutions for proteomics and phospho-proteomics data analysis and visualization. RokaiXplorer streamlines data processing, analysis, and visualization through an interactive online interface, making it accessible to researchers without specialized training in proteomics or data science. With its comprehensive suite of modules, RokaiXplorer facilitates phospho-proteomic analysis at the level of phosphosites, proteins, kinases, biological processes, and pathways. The tool offers functionalities such as data normalization, statistical testing, activity inference, pathway enrichment, subgroup analysis, automated report generation, and multiple visualizations, including volcano plots, bar plots, heat maps, and network views. As a unique feature, RokaiXplorer allows researchers to effortlessly deploy their own data browsers, enabling interactive sharing of research data and findings. Overall, RokaiXplorer fills an important gap in phospho-proteomic data analysis by providing the ability to comprehensively analyze data at multiple levels within a single application. Availability and implementation: Access RokaiXplorer at: http://explorer.rokai.io.

Identifiers

PMID39310046
PMCPMC11415779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.