Evidence map›Paper›PMID 39309794›Full record

ArticleHeliyon2024

DNA methylation changes in the genome of patients with hypogonadotropic hypogonadism.

Erina Suzuki, Kazuhiko Nakabayashi, Saki Aoto, Tsutomu Ogata, Yoko Kuroki, Mami Miyado, Maki Fukami, Keiko Matsubara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erina SuzukiDepartment of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
Kazuhiko NakabayashiDepartment of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
Saki AotoMedical Genome Center, National Center for Child Health and Development, Tokyo, Japan.
Tsutomu OgataDepartment of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yoko KurokiDepartment of Genome Medicine, National Research Institute for Child Health and Development, Tokyo, Japan.
Mami MiyadoDepartment of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
Maki FukamiDepartment of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
Keiko MatsubaraDepartment of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although some Mendelian neurodevelopmental disorders have been shown to entail specific DNA methylation changes designated as epi-signatures, it remains unknown whether epi-signatures are consistent features of other genetic disorders. Here, we analyzed DNA methylation profiles of patients with hypogonadotropic hypogonadism (HH), a rare neuroendocrine disorder typically caused by monogenic or oligogenic mutations. First, we performed microarray-based genome-wide methylation analyses of nine patients with HH due to

Indexed as

DNA methylationEpi-signatureGenome-wide analysisKallmann syndrome

Identifiers

PMID39309794
PMCPMC11416509

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.