Evidence map›Paper›PMID 39309654›Full record

ArticleRSC advances2024

Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles.

Yalin Qi, Hesong Han, Albert Liu, Sheng Zhao, Atip Lawanprasert, Josefine Eilsø Nielsen, Hema Choudhary, Dengpan Liang, Annelise E Barron, Niren Murthy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Poly(sarcosine) Lipid Synthesis From COMacromolecular rapid communications · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yalin QiDepartment of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.ORCID https://orcid.org/0000-0002-7040-8525
Hesong HanDepartment of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.ORCID https://orcid.org/0000-0001-5545-5238
Albert LiuDepartment of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.
Sheng ZhaoDepartment of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.
Atip LawanprasertDepartment of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.
Josefine Eilsø NielsenDepartment of Bioengineering, School of Medicine, Stanford University Stanford California 94305 USA.
Hema ChoudharyDepartment of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.
Dengpan LiangDepartment of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.
Annelise E BarronDepartment of Bioengineering, School of Medicine, Stanford University Stanford California 94305 USA.ORCID https://orcid.org/0000-0002-0735-6873
Niren MurthyDepartment of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.ORCID https://orcid.org/0000-0002-7815-7337

Funding

Role of Innate Immune Dysregulation in the Etiology of DementiaDP1AG072438 · NIA · STANFORD UNIVERSITY · PI BARRON, ANNELISE EMILY · 2020 to 2024
$5.2M
NIA NIH HHS DP1 AG072438
6 · The paper itself

Abstract

Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.

Identifiers

PMID39309654
PMCPMC11414743

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.