Evidence map›Paper›PMID 39309552›Full record

ArticleBioinformation2024

Interpreting and visualizing pathway analyses using embedding representations with PAVER.

William G Ryan V, Ali Sajid Imami, Hunter Ali Sajid, John Vergis, Xiaolu Zhang, Jarek Meller, Rammohan Shukla, Robert McCullumsmith

Abstract read
In one paragraph

Article in Bioinformation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Pathway Analysis Interpretation in the Multi-Omic Era.Biotech (Basel (Switzerland)) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William G Ryan VDepartment of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Ali Sajid ImamiDepartment of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Hunter Ali SajidDepartment of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
John VergisDepartment of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Xiaolu ZhangDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Jarek MellerDepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Rammohan ShuklaDepartment of Zoology & Physiology, College of Agriculture, Life Sciences and Natural Resources, University of Wyoming, Laramie, WY, USA.
Robert McCullumsmithDepartment of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.

Funding

Translational assessment of brain bioenergetic function in schizophreniaR01MH121102 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI MARANO, CHRISTOPHER, MCCULLUMSMITH, ROBERT E · 2020 to 2024
$3.7M
Development of Attenuated Furoxans as Novel Therapies for Alzheimer's DiseaseR01AG057598 · NIA · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SCHIEFER, ISAAC T · 2018 to 2022
$2.3M
Cell-specific analysis of sub-kinomes in schizophreniaR01MH107487 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI MCCULLUMSMITH, ROBERT E, MELLER, JAREK · 2016 to 2020
$1.9M
Training in Molecular and translational Cell DynamicsT32GM144873 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI AVIDOR-REISS, TOMER, DWORKIN, LANCE DOUGLAS · 2022 to 2024
$1.3M
NIA NIH HHS R01 AG057598NIGMS NIH HHS T32 GM144873NIMH NIH HHS R01 MH107487NIMH NIH HHS R01 MH121102
6 · The paper itself

Abstract

Omics studies use large-scale high-throughput data to explain changes underlying different traits or conditions. However, omics analysis often results in long lists of pathways that are difficult to interpret. Therefore, it is of interest to describe a tool named PAVER (Pathway Analysis Visualization with Embedding Representations) for large scale genomic analysis. PAVER curates similar pathways into groups, identifies the pathway most representative of each group, and provides publication-ready intuitive visualizations. PAVER clusters pathways defined by their vector embedding representations and then identifies the term most cosine similar to its respective cluster's average embedding. PAVER can integrate multiple pathway analyses, highlight relevant biological insights, and work with any pathway database.

Indexed as

Biocurationcomputational biologygene expression profilingpathway analysissystems biology

Identifiers

PMID39309552
PMCPMC11414338

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.