Evidence map›Paper›PMID 39309509›Full record

ArticleActa pharmaceutica Sinica. B2024

Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing.

Wenkang Fu, Yanyan Lin, Mingzhen Bai, Jia Yao, Chongfei Huang, Long Gao, Ningning Mi, Haidong Ma, Liang Tian, Ping Yue and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
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  7. Review
  8. Organoids and spheroids: advancedFrontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Wenkang FuThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.
Yanyan LinDepartment of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730030, China.
Mingzhen BaiThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.
Jia YaoThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.
Chongfei HuangThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.
Long GaoThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.
Ningning MiThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.
Haidong MaThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.
Liang TianThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.
Ping YueDepartment of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730030, China.
Yong ZhangDepartment of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730030, China.
Jinduo ZhangDepartment of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730030, China.
Yanxian RenDepartment of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730030, China.
Liyun DingSchool of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China.
Lunzhi DaiNational Clinical Research Center for Geriatrics and Department of General Practice, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Joseph W LeungDivision of Gastroenterology, UC Davis Medical Center and Sacramento VA Medical Center, Sacramento, CA 95817, USA.
Jinqiu YuanClinical Research Center, Big Data Center, the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
Wenhua ZhangSchool of Life Sciences, Lanzhou University, Lanzhou 730000, China.
Wenbo MengThe First School of Clinical Medicne, Lanzhou University, Lanzhou 730030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a bile duct malignancy with a dismal prognosis. This study systematically investigated the role of the ribosomal protein S6 (

Indexed as

Alternative splicingCholangiocarcinomaMinichromosome maintenance complex component 7p53Patient-derived organoidsRibosomal protein S6Vivo morpholino

Identifiers

PMID39309509
PMCPMC11413689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.