Evidence map›Paper›PMID 39309445›Full record

ArticleInternational journal of biological sciences2024

METTL18 functions as a Phenotypic Regulator in Src-Dependent Oncogenic Responses of HER2-Negative Breast Cancer.

Han Gyung Kim, Ji Hye Kim, Kyung-Hee Kim, Byong Chul Yoo, Sung-Ung Kang, Young Bong Kim, Sangmin Kim, Hyun-June Paik, Jeong Eon Lee, Seok Jin Nam and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Han Gyung KimDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Ji Hye KimDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kyung-Hee KimResearch Institute, National Cancer Center, Goyang 10408, Republic of Korea.
Byong Chul YooResearch Institute, National Cancer Center, Goyang 10408, Republic of Korea.
Sung-Ung KangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Young Bong KimDepartment of Bio-industrial Technologies, Konkuk University, Seoul 05029, Republic of Korea.
Sangmin KimBreast Cancer Center, Samsung Medical Center, Seoul 06351, Republic of Korea.
Hyun-June PaikDepartment of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.
Jeong Eon LeeDivision of Breast, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
Seok Jin NamDivision of Breast, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
Narayanan ParameswaranDepartment of Physiology and Division of Pathology, Michigan State University, East Lansing, MI 48824, USA.
Jeung-Whan HanResearch Center for Epigenome Regulation, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Balachandran ManavalanDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Jae Youl ChoDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methyltransferase-like (METTL)18 has histidine methyltransferase activity on the RPL3 protein and is involved in ribosome biosynthesis and translation elongations. Several studies have reported that actin polymerization serves as a Src regulator, and HSP90 is involved in forming polymerized actin bundles. To understand the role of METTL18 in breast cancer and to demonstrate the importance of METTL18 in HER-2 negative breast cancer metastasis, we used biochemical, molecular biological, and immunological approaches

Indexed as

Breast NeoplasmsErb-b2 Receptor Tyrosine KinasesMethyltransferasesProto-Oncogene Massrc-Family KinasesAnimalsCell Line, TumorFemaleHSP90 Heat-Shock ProteinsHumansMiceMice, NudePhosphorylationRibosomal ProteinsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesHSP90 Heat-Shock ProteinsMAS1 protein, humanMethyltransferasesProto-Oncogene MasRibosomal Proteinssrc-Family Kinasesactinbreast cancerhistidine methyltransferaseHSP90invasionmetastasisMETTL18migrationRPL3 methylationSrc kinase

Identifiers

PMID39309445
PMCPMC11414398

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.