Evidence map›Paper›PMID 39309275›Full record

ArticleStatistica Neerlandica2023

Estimating random effects in a finite Markov chain with absorbing states: Application to cognitive data.

Pei Wang, Erin L Abner, Changrui Liu, David W Fardo, Frederick A Schmitt, Gregory A Jicha, Linda J Van Eldik, Richard J Kryscio

Abstract read
In one paragraph

Article in Statistica Neerlandica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pei WangDepartment of Statistics, Miami University, Oxford, Ohio.
Erin L AbnerDepartment of Epidemiology, University of Kentucky, Lexington, Kentucky.
Changrui LiuDepartment of Statistics, University of Kentucky, Lexington, Kentucky.ORCID 0000-0002-3051-6126
David W FardoAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.
Frederick A SchmittAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.
Gregory A JichaAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.
Linda J Van EldikAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.
Richard J KryscioAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.ORCID 0000-0002-2775-1184

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Restoration of Dopaminergic Function in Parkinson's DiseaseP50NS039787 · NINDS · UNIVERSITY OF KENTUCKY · PI GERHARDT, GREG A. · 1999 to 2009
$10.9M
Role of impaired cognitive states & risk factors in conversion to mixed dementiasR01AG038651 · NIA · UNIVERSITY OF KENTUCKY · PI ABNER, ERIN, KRYSCIO, RICHARD J. · 2011 to 2023
$6.1M
Genomic Architecture of a Key Alzheimer's Disease Mimic: CARTSR56AG057191 · NIA · UNIVERSITY OF KENTUCKY · PI FARDO, DAVID WILLIAM · 2019 to 2020
$1.1M
NCATS NIH HHS UL1 TR001998NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG038651NIA NIH HHS R56 AG057191NINDS NIH HHS P50 NS039787
6 · The paper itself

Abstract

Finite Markov chains with absorbing states are popular tools for analyzing longitudinal data with categorical responses. The one step transition probabilities can be defined in terms of fixed and random effects but it is difficult to estimate these effects due to many unknown parameters. In this article we propose a three-step estimation method. In the first step the fixed effects are estimated by using a marginal likelihood function, in the second step the random effects are estimated after substituting the estimated fixed effects into a joint likelihood function defined as a h-likelihood, and in the third step the covariance matrix for the vector of random effects is estimated using the Hessian matrix for this likelihood function. An application involving an analysis of longitudinal cognitive data is used to illustrate the method.

Indexed as

cognitive assessmentsh-likelihoodmarginal likelihoodMarkov chainsmultinomial logistic regressionrandom effect

Identifiers

PMID39309275
PMCPMC11415262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.