ArticleWellcome open research2024
RedLionfish - fast Richardson-Lucy Deconvolution package for efficient point spread function suppression in volumetric data.
Article in Wellcome open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Imaging-Based Spatial Transcriptomics: Data Interpretation Methods and Biomedical Applications.Biology · 2026Review
- Layer-specific input to medial prefrontal cortex is linked to stress susceptibility.Translational psychiatry · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
The experimental limitations with optics observed in many microscopy and astronomy instruments result in detrimental effects for the imaging of objects. This can be generally described mathematically as a convolution of the real object image with the point spread function that characterizes the optical system. The popular Richardson-Lucy (RL) deconvolution algorithm is widely used for the inverse process of restoring the data without these optical aberrations, often a critical step in data processing of experimental data. Here we present the versatile RedLionfish python package, that was written to make the RL deconvolution of volumetric (3D) data easier to run, very fast (by exploiting GPU computing capabilities) and with automatic handling of hardware limitations for large datasets. It can be used programmatically in Python/numpy using conda or PyPi package managers, or with a graphical user interface as a napari plugin.
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