Evidence map›Paper›PMID 39309138›Full record

ArticleCommunications materials2024

Ascorbyl palmitate nanofiber-reinforced hydrogels for drug delivery in soft issues.

Yasmeen Shamiya, Aishik Chakraborty, Alap Ali Zahid, Nicholas Bainbridge, Jingyuan Guan, Biao Feng, Dominic Pjontek, Subrata Chakrabarti, Arghya Paul

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yasmeen ShamiyaDepartment of Chemistry, The University of Western Ontario, London, ON Canada.
Aishik ChakrabortyDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON Canada.
Alap Ali ZahidDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON Canada.
Nicholas BainbridgeDepartment of Chemistry, The University of Western Ontario, London, ON Canada.
Jingyuan GuanDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON Canada.
Biao FengDepartment of Pathology and Laboratory Medicine, The University of Western Ontario, London, ON Canada.
Dominic PjontekDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON Canada.
Subrata ChakrabartiDepartment of Pathology and Laboratory Medicine, The University of Western Ontario, London, ON Canada.
Arghya PaulDepartment of Chemistry, The University of Western Ontario, London, ON Canada.ORCID 0000-0003-4788-0378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanofiber-based hydrogel delivery systems have recently shown great potential in biomedical applications, specifically due to their high surface-to-volume ratio of ultra-fine nanofibers and their ability to carry low solubility drugs. Herein, we introduce a visible light-triggered in situ-gelling drug vehicle (GAP Gel) composed of ascorbyl palmitate (AP) nanofibers and gelatin methacryloyl polymer. AP nanofibers form self-assembled structures through intermolecular interactions with a hydrophobic drug-loading core. We demonstrate that the hydrophilic periphery of AP nanofibers allows them to interact with other hydrophilic molecules via hydrogen bonds. The presence of AP nanofibers significantly enhances the viscoelasticity of GAP Gel in a concentration-dependent manner. Further, GAP Gel shows in vitro biocompatibility and sustained drug delivery efficacy when loaded with a hydrophobic antibiotic. Likewise, GAP Gel shows excellent in vivo biocompatibility when implanted in immunocompetent mice in various forms. Lastly, GAP Gels maintain cell viability when cultured in a 3D-environment over 7 days, establishing it as a promising and versatile hydrogel platform for the delivery of biotherapeutics.

Indexed as

Biomedical materialsGels and hydrogels

Identifiers

PMID39309138
PMCPMC11415299

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.