ReviewJournal of the Endocrine Society2024
Sexual Dimorphism in the Musculoskeletal System: Sex Hormones and Beyond.
Review in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness.Intensive care medicine · 2025Trial
- Craniofacial size in individuals with supernumerary teeth: A multicenter geometric morphometric study.BMC oral health · 2026Article
- Heterochronic activation of TGF-β signaling drives the diversity of the avian sterna.Nature communications · 2026Article
- Multivariate genetic analysis reveals three distinct pathological dimensions in musculoskeletal disorders.Nature communications · 2026Article
- Article
- Dynamic transcriptome analysis highlights collagen-integrin-mediated extracellular matrix remodeling underlying sexual dimorphism in the amplexus muscle of Bufo gargarizans.Biology of sex differences · 2026Article
- Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo.Acta biomaterialia · 2026Article
- Chromosomal and hormonal factors involved in human sexual dimorphism.Endocrine journal · 2026Review
- Morphological, Morphometric and Phaneroptic Variations of the Mediterranean Donkey and Tunisian Perspective on Conservation and Breeding.Animals : an open access journal from MDPI · 2026Article
- Sex- and Age-Specific Associations Between Visceral Fat-to-Muscle Ratio and Bone Mineral Density in Children and Adolescents.International journal of endocrinology · 2026Article
- Comparative morphometric analysis of the clavicle in male and female human cadavers: Implications for forensic identification.Bioinformation · 2026Article
- Coupling geometric morphometrics and machine learning for mandibular sex estimation in Late Pleistocene and Late Modern populations.Scientific reports · 2025Article
- Risk factors for reoperation following operative fixation of patella fractures.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Body Composition Alterations in Patients with Chronic Stroke: A Cross-Sectional Study.Journal of musculoskeletal & neuronal interactions · 2025Article
- Why are men taller than women?: Genetic and hormonal factors involved in sex differences in human height.Journal of human genetics · 2025Article
- A Comparative Analysis of Grip Strength Evaluation Methods in a Large Cohort of Aged Mice.Journal of cachexia, sarcopenia and muscle · 2025Article
- Article
- Biological Sex Is Under-Reported in Cartilage-Related Preclinical Research: A Cross-Sectional Analysis.JOR spine · 2025Article
- Sex estimation using humerus volume in a Korean population with varying bone preservation.Scientific reports · 2025Article
- The impact of iodinated contrast medium on bone mineral density (BMD) quantification in computed tomography: a monocentric retrospective study evaluating phases, sex and age differences.La Radiologia medica · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mounting evidence indicates that whereas some fundamental aspects of bone cell differentiation and function are similar in females and males, there is a clear contribution of sex/gender on the effects of signaling molecules on bone mass and strength and, consequently, on the effects of pharmacologic approaches to treat skeletal disorders. However, until recently, most studies were designed and performed using only 1 sex, resulting in a scarcity of published information on sexual dimorphism of the musculoskeletal system, including the mandible/masticatory muscles and the axial and appendicular bones and skeletal muscles. Further, it is now recognized that scientific rigor requires the study of both males and females. Therefore, there is an increasing need to understand the molecular and cellular basis for the differential outcomes of genetic manipulations and therapeutic agent administration depending on the sex of the experimental animals. Studies have shown higher muscle mass, cancellous bone mass, and long bone width in males compared with females as well as different traits in the pelvis and the skull, which are usually used for gender identification in forensic anthropology. Yet, most reports focus on the role of sex hormones, in particular, the consequences of estrogen deficiency with menopause in humans and in ovariectomized animal models. In addition, emerging data is starting to unveil the effects of gender-affirming hormonal therapy on the musculoskeletal system. We summarize here the current knowledge on the sex/gender-dependent phenotypic characteristics of the bone and skeletal muscles in humans and rodents, highlighting studies in which side by side comparisons were made.
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Registered trials
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