Evidence map›Paper›PMID 39309006›Full record

ArticleFrontiers in pharmacology2024

Glomerular injury induced by vinyl carbamate in A/J inbred mice: a novel model of membranoproliferative glomerulonephritis.

Athena Y Gong, Ying Jin Qiao, Mengxuan Chen, Zubia Alam, Deepak K Malhotra, Lance Dworkin, Wenjun Ju, William T Gunning

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Athena Y GongCollege of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, United States.
Ying Jin QiaoDepartment of Medicine, University of Toledo College of Medicine, Toledo, OH, United States.
Mengxuan ChenDepartment of Medicine, University of Toledo College of Medicine, Toledo, OH, United States.
Zubia AlamDepartment of Medicine, University of Toledo College of Medicine, Toledo, OH, United States.
Deepak K MalhotraDepartment of Medicine, University of Toledo College of Medicine, Toledo, OH, United States.
Lance DworkinDepartment of Medicine, University of Toledo College of Medicine, Toledo, OH, United States.
Wenjun JuMichigan O'Brien Kidney National Resource Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.
William T GunningDepartment of Pathology, Medical College of Ohio at University of Toledo, Toledo, OH, United States.

Funding

University of Michigan O'Brien Kidney Translational Resource Center (MKTC)U54DK137314 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Salim Hayek · 2023 to 2026
$4.7M
The Melanocortinergic pathway inglomerular diseaseR01DK114006 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI GONG, RUJUN · 2017 to 2021
$1.8M
Role of GSK3beta in diabetic kidney diseaseR01DK133203 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI Rujun Gong · 2022 to 2026
$1.7M
NIDDK NIH HHS R01 DK114006NIDDK NIH HHS R01 DK133203NIDDK NIH HHS U54 DK137314
6 · The paper itself

Abstract

Ethyl carbamate (EC) is a process contaminant found in fermented foods and alcoholic beverages. Metabolic conversion of ethyl carbamate generates vinyl carbamate (VC), a carcinogenic metabolite. EC, as a Group 2A probable human carcinogen, and the more potent VC, are known to cause tumors in rodents. However, their effects on the kidney are unknown and were explored here. Female A/J inbred mice received an intraperitoneal injection of vehicle or VC. Beginning 5 weeks after VC injection, mice showed signs of moribund state. Mouse necropsies revealed renal glomerular injury that histopathologically recapitulated human membranoproliferative glomerulonephritis (MPGN), as evidenced by light microscopy, immunostaining for immunoglobulins and complements, and electron microscopy. To determine the molecular pathomechanisms, a

Indexed as

C3 glomerulonephritisC3 glomerulopathycomplementdense deposit diseaseglomerular endothelial cells

Identifiers

PMID39309006
PMCPMC11412833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.