Evidence map›Paper›PMID 39308988›Full record

ReviewTremor and other hyperkinetic movements (New York, N.Y.)2024

Beyond Pallidal or Subthalamic Deep Brain Stimulation to Treat Dystonia.

Vedant Garg, Venkat Srikar Lavu, Grace Hey, Brett Winter, Marcos Santana Firme, Justin D Hilliard, Coralie De Hemptinne, Michael S Okun, Joshua K Wong

Abstract readReview
In one paragraph

Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vedant GargDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-0519-1673
Venkat Srikar LavuDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0009-0001-7046-5431
Grace HeyDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-9838-7738
Brett WinterDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Marcos Santana FirmeDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Justin D HilliardDepartment of Neurosurgery, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-9688-057X
Coralie De HemptinneDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-2780-3666
Michael S OkunDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-6247-9358
Joshua K WongDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-4632-3417

Funding

Multisite adaptive brain stimulation for multidimensional treatment of refractory chronic painUH3NS115631 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHIRVALKAR, PRASAD · 2019 to 2023
$6.9M
Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain StimulationUH3NS119844 · NINDS · UNIVERSITY OF FLORIDA · PI BUTSON, CHRISTOPHER R, GUNDUZ, AYSEGUL · 2021 to 2025
$5.0M
Web-based Automated Imaging Differentiation of ParkinsonismU01NS119562 · NINDS · UNIVERSITY OF FLORIDA · PI BARMPOUTIS, ANGELOS, OKUN, MICHAEL S · 2021 to 2025
$4.8M
Technology development for closed-loop deep brain stimulation to treat refractory neuropathic painUH3NS109556 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, EDWARD, STARR, PHILIP ANDREW · 2019 to 2023
$3.0M
Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
THE HUMAN THALAMOCORTICAL NETWORK IN TOURETTE SYNDROMER01NS096008 · NINDS · UNIVERSITY OF FLORIDA · PI GUNDUZ, AYSEGUL, OKUN, MICHAEL S · 2016 to 2020
$1.8M
University of Florida R25 Early Research Program for Neurology and Neurosurgery ResidentsR25NS108939 · NINDS · UNIVERSITY OF FLORIDA · PI HOH, BRIAN LIM, OKUN, MICHAEL S · 2019 to 2024
$537k
NCATS NIH HHS KL2 TR001429NINDS NIH HHS R01 NS096008NINDS NIH HHS R25 NS108939NINDS NIH HHS U01 NS119562NINDS NIH HHS UH3 NS109556NINDS NIH HHS UH3 NS115631NINDS NIH HHS UH3 NS119844NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

Deep brain stimulation of the subthalamic nucleus and globus pallidus internus is approved by the Food and Drug Administration for treating dystonia. Both targets have shown effectiveness in improving symptoms, but post-operative outcomes can vary significantly among patients. This variability has led researchers to explore alternative neuromodulation targets that might offer more consistent results. Emerging research has highlighted several promising new targets for DBS in dystonia. This review examines pre-clinical and clinical data on novel DBS targets for dystonia and explores non-invasive neuromodulation studies that shed light on the disease's underlying pathological circuitry.

Indexed as

Deep Brain StimulationDystoniaGlobus PallidusSubthalamic NucleusAnimalsDystonic DisordersHumanscerebellumdeep brain stimulationdystonianeuromodulationthalamus

Identifiers

PMID39308988
PMCPMC11414463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.