Evidence map›Paper›PMID 39308863›Full record

ArticleFrontiers in immunology2024

Inter-individual and inter-regional variability of breast milk antibody reactivity to bacterial lipopolysaccharides.

Lisa Crone, Jens Sobek, Nicole Müller, Tanja Restin, Dirk Bassler, Daniela Paganini, Michael B Zimmermann, Patricia Zarnovican, Françoise H Routier, Tais Romero-Uruñuela and 2 more

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In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Defined Glycan Ligands for Detecting Rare l-Sugar-Binding Proteins.Journal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lisa CroneInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Jens SobekFunctional Genomics Center Zurich, Eidgenössische Technische Hochschule (ETH) Zurich and University of Zurich, Zurich, Switzerland.
Nicole MüllerInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Tanja RestinInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Dirk BasslerDepartment of Neonatology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Daniela PaganiniLaboratory of Human Nutrition, Department of Health Sciences and Technology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland.
Michael B ZimmermannMedical Research Council (MRC) Translational Immune Discovery Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Patricia ZarnovicanDepartment of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.
Françoise H RoutierDepartment of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.
Tais Romero-UruñuelaBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
Luis IzquierdoBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
Thierry HennetInstitute of Physiology, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast milk is a vital source of nutrients, prebiotics, probiotics, and protective factors, including antibodies, immune cells and antimicrobial proteins. Using bacterial lipopolysaccharide arrays, we investigated the reactivity and specificity of breast milk antibodies towards microbial antigens, comparing samples from rural Kenya and urban Switzerland. Results showed considerable variability in antibody reactivity both within and between these locations. Kenyan breast milk demonstrated broad reactivity to bacterial lipopolysaccharides, likely due to increased microbial exposure. Antibodies primarily recognized the O-antigens of lipopolysaccharides and showed strong binding to specific carbohydrate motifs. Notably, antibodies against specific

Indexed as

LipopolysaccharidesMilk, HumanAdultAntibodies, BacterialCross ReactionsEscherichia coliFemaleHumansKenyaO AntigensSwitzerlandAntibodies, BacterialLipopolysaccharidesO Antigensantigen mimicryglycaninfectionlactationmicroarraynatural protectionO-antigen

Identifiers

PMID39308863
PMCPMC11412857

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.