Evidence map›Paper›PMID 39308790›Full record

ArticleThe World Allergy Organization journal2024

Hydrogen inhalation: A novel approach to alleviating allergic rhinitis symptoms by modulating nasal flora.

Nan Wang, Qianzi Ma, Jiayuan Zhai, Yanlu Che, Junjie Liu, Tianwei Tang, Yanan Sun, Jingting Wang, Wanchao Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nan WangDepartment of Otorhinolaryngology, Head and Neck Surgery, Qingdao Women and Children's Hospital, Qingdao, China.
Qianzi MaDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
Jiayuan ZhaiDepartment of Anesthesiology, The Sixth Affiliated Hospital, Harbin Medical University, Harbin, China.
Yanlu CheDepartment of Otorhinolaryngology, Head and Neck Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Junjie LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
Tianwei TangDepartment of Anesthesiology, The Sixth Affiliated Hospital, Harbin Medical University, Harbin, China.
Yanan SunDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
Jingting WangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
Wanchao YangDepartment of Anesthesiology, The Sixth Affiliated Hospital, Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Allergic rhinitis (AR) is an allergic reaction dominated by the Th2 immune response in the nasal mucosa. The bacterial infection process affects the balance between Th1 and Th2 immune responses, and the level of exposure to environmental flora is closely related to the development of AR. Hydrogen (H Methods: Serum eosinophil count (EOS), immunoglobulin E (IgE) concentration, visual analog scale (VAS), total nasal symptom score (TNSS), and rhinoconjunctivitis quality of life questionnaire (RQLQ) were observed before and after hydrogen inhalation in AR patients. Skin prick test (SPT) was used to determine allergen sensitisation. Community composition and relative abundance of nasal flora were examined before and after hydrogen inhalation and in normal subjects using 16S rRNA gene sequencing. Results: There were no adverse reactions during and after hydrogen inhalation in AR patients, with a favorable safety profile and significant improvements in VAS, TNSS, EOS, and IgE (P < 0.05). Cavity flora 16S rRNA gene sequencing showed higher abundance of Ruminococcus and Erysipelotrichaceae flora in the nasal cavity of AR patients than in normal subjects, and their abundance could be down-regulated after H Conclusions: H Trial registration: This trial was registered in the China Clinical Trial Registry (Registration No. ChiCTR2200062253).

Indexed as

Allergic rhinitisBlautia_faecisErysipelotrichaceaeH2Nasal floraRuminococcus

Identifiers

PMID39308790
PMCPMC11415863

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.