Evidence map›Paper›PMID 39308524›Full record

ArticleOncology research2024

Metformin promotes anti-tumor immunity in

Zhiguo Wang, Kunlin Li, Conghua Lu, Mingxia Feng, Caiyu Lin, Guofang Yin, Dan Luo, Wenyi Liu, Kaiyu Jin, Yuanyao Dou and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhiguo WangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Kunlin LiDepartment of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Conghua LuDepartment of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Mingxia FengDepartment of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Caiyu LinDepartment of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Guofang YinDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Dan LuoDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Wenyi LiuDepartment of Trauma Medical Center, Daping Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, 400042, China.
Kaiyu JinDepartment of Respiratory Disease, People's Hospital of Xuyong County, Luzhou, 646000, China.
Yuanyao DouDepartment of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
D I WuDepartment of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Jie ZhengDepartment of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Kejun ZhangDepartment of Outpatients, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
L I LiDepartment of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Xianming FanDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Metformin has pleiotropic effects beyond glucose reduction, including tumor inhibition and immune regulation. It enhanced the anti-tumor effects of programmed cell death protein 1 (PD-1) inhibitors in serine/threonine kinase 11 ( Methods: We performed untargeted metabolomics using liquid chromatography (LC)-mass spectrometry (MS)/MS system and conducted cell experiments to verify the results of bioinformatics analysis. Results: According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, most metabolites were annotated into metabolism, including nucleotide metabolism. Next, the differentially expressed metabolites in H460 (refers to H460 cells), H460_met (refers to metformin-treated H460 cells), and H460_KO_met (refers to metformin-treated Conclusion: Relying on AXIN1, metformin upregulated multiple nucleotide metabolites which promoted STING signaling and the killing of activated T cells in

Indexed as

AMP-Activated Protein Kinase KinasesAxin ProteinCarcinoma, Non-Small-Cell LungLung NeoplasmsMetforminMutationNucleotidesProtein Serine-Threonine KinasesCell Line, TumorGene Expression Regulation, NeoplasticHumansMetabolomicsUp-RegulationAMP-Activated Protein Kinase KinasesAXIN1 protein, humanAxin ProteinMetforminNucleotidesProtein Serine-Threonine KinasesSTK11 protein, humanAxis inhibition protein 1 (AXIN1)Lung cancerMetforminNucleotide metabolitesSerine/threonine kinase 11 (STK11)

Identifiers

PMID39308524
PMCPMC11413838

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.