Evidence map›Paper›PMID 39308474›Full record

ArticleThe Neurohospitalist2024

Rates of Acute Brain Injury Among Severely Hypertensive Patients Seen in the Emergency Department.

Amgad Ishak, Hooman Kamel, Jed H Kaiser, Vanessa Liao, Jenny Rotblat, Anokhi Pawar, Richard Lappin, Junaid Razzak, Halina White, Catherine Ng and 1 more

Abstract read
In one paragraph

Article in The Neurohospitalist, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amgad IshakClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Hooman KamelClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0002-5745-0307
Jed H KaiserClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Vanessa LiaoClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Jenny RotblatClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Anokhi PawarClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Richard LappinDepartment of Emergency Medicine, Weill Cornell Medicine, New York, NY, USA.
Junaid RazzakDepartment of Emergency Medicine, Weill Cornell Medicine, New York, NY, USA.
Halina WhiteClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Catherine NgInformation Technologies & Services Department, Weill Cornell Medicine, New York, NY, USA.
Ava L LibermanClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0003-0184-6035

Funding

AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenicstroke (ARCADIA)U01NS095869 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRODERICK, JOSEPH PAUL, KAMEL, HOOMAN · 2017 to 2022
$22.0M
Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6M
JHU-Afghanistan-Pakistan Collaborative Trauma and Injury Research TrainingD43TW007292 · FIC · JOHNS HOPKINS UNIVERSITY · PI Nadeem Ullah Khan, Junaid Abdul Razzak · 2005 to 2026
$4.7M
MRI Detection of CarotId Plaques as a mecHanism for Embolic strokes of undeteRmined source (MRI DECIPHER)R01HL144541 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, KAMEL, HOOMAN · 2019 to 2023
$3.9M
Quantitative Susceptibility Mapping for Stroke Risk Prediction of Vulnerable Carotid PlaquesR01NS123576 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Ajay Gupta, Hooman Kamel · 2022 to 2026
$3.3M
iRise: Willingness of Low-and Middle-Income Country-based Health Workers to Respond to Public Health Emergencies and Disasters - an mHealth Intervention StudyR21TW012210 · FIC · JOHNS HOPKINS UNIVERSITY · PI ASAD, NARGIS, BARNETT, DANIEL JEREMY · 2021 to 2022
$395k
Feasibility and Efficacy of Ambulance-Based mhealth for Pediatric Emergencies (FEAMER) TrialR21HD103049 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAZZAK, JUNAID ABDUL · 2022 to 2023
$386k
MOLECULAR GENETICS OF ZEBRAFISH PIGMENT CELL DEVELOPMENTF32NS010764 · NINDS · UNIVERSITY OF WASHINGTON · PI LISTER, JAMES A · 1998 to 2001
$73k
FIC NIH HHS D43 TW007292FIC NIH HHS R21 TW012210NHLBI NIH HHS R01 HL144541NICHD NIH HHS R21 HD103049NINDS NIH HHS F32 NS010764NINDS NIH HHS R01 NS123576NINDS NIH HHS U01 NS095869NINDS NIH HHS U01 NS106513
6 · The paper itself

Abstract

Background: Identifying patients with acute brain injury among patients who present to the Emergency Department (ED) with severe hypertension can be challenging. We explored rates of brain injury in a cohort of ED patients with severe hypertension in whom acute target-organ damage was or was not initially suspected. Methods: We conducted a retrospective chart-review study at two different hospitals within the same urban health system. Consecutive adult patients seen from 10/1/2020 to 5/1/2022 with a systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥120 mmHg were included. Results: A total of 972 patients met our eligibility criteria. The average age was 59 years (SD: 16.5), 454 (46.7%) were women, and 582 (59.9%) were non-White. A total of 186/972 (19.1%) patients were initially thought to have acute target-organ damage in the ED with 97/186 (52.2%) diagnosed with stroke or TIA. The remaining 786/972 (80.9%) patients were not initially diagnosed with target-organ damage (hypertensive urgency [HU]). Of the 786 patients with HU, a head CT was obtained in 216/786 (27.7%) and brain MRI in 74/786 (9.4%). Of the HU patients with a brain MRI, 23/74 (31.1%) had acute abnormalities; most abnormalities on brain MRI (17/23 [73.9%]) were not seen on preceding head CT. Conclusions: In a multicenter study of ED patients, nearly 1 in 5 patients though to have HU who eventually underwent brain MRI had unexpected acute neurological findings, though brain MR was obtained in only 9%.

Indexed as

emergency medicinehypertensive crisishypertensive emergencyhypertensive urgencystroke

Identifiers

PMID39308474
PMCPMC11412462

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.