ArticleAdvanced materials (Deerfield Beach, Fla.)2024
Single Atom Engineered Antibiotics Overcome Bacterial Resistance.
Article in Advanced materials (Deerfield Beach, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Single-atom nanozymes in nanomedicine: catalytic precision, mechanistic insights, and translational opportunities.Chemical science · 2026Review
- Intracellular Proton Enrichment Drives Unified Dual-Cofactor Regeneration for Biohybrid COAngewandte Chemie (International ed. in English) · 2026Article
- Breaking the antimicrobial resistance dilemma: marine natural products, a treasure trove for the development of new anti-Marine life science & technology · 2026Review
- Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanomaterial-Based Inkjet Printing for Electrochemical Sensing.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Methylation-Induced Permanent Charge Polarization in Covalent Organic Frameworks for Visible Light-Driven Water Decontamination and Disinfection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Printing technologies for monitoring crop health.Nature communications · 2026Review
- Redox-Switchable Single-Atom Catalyst Enables Efficient Aqueous Hydroxymethylfurfural Oxidation.ACS catalysis · 2025Article
- A label-free impedimetric immunosensor based on nitrogen-doped graphene acid for sensitive detection of vitamin DMikrochimica acta · 2025Article
- Regulation of MXene Membranes with β-Lactoglobulin Nanofiber-Templated CuS Nanoparticles for Photothermal Antibacterial Effect.Polymers · 2025Article
- Iron Single-Atom Catalysts Anchored on Defect-Engineered N‑Doped Graphene Reveal an Interplay between COACS sustainable chemistry & engineering · 2025Article
- A calcium-copper-based zeolite with dual functions of hemostatic and antibacterial properties.RSC advances · 2025Article
- Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria.Microorganisms · 2025Review
- Single Atom Engineered Antibiotics Overcome Bacterial Resistance.Advanced materials (Deerfield Beach, Fla.) · 2024Article
Corrections and comments
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Authors and funding
24 authors.
Funding
Abstract
The outbreak of antibiotic-resistant bacteria, or "superbugs", poses a global public health hazard due to their resilience against the most effective last-line antibiotics. Identifying potent antibacterial agents capable of evading bacterial resistance mechanisms represents the ultimate defense strategy. This study shows that -the otherwise essential micronutrient- manganese turns into a broad-spectrum potent antibiotic when coordinated with a carboxylated nitrogen-doped graphene. This antibiotic material (termed NGA-Mn) not only inhibits the growth of a wide spectrum of multidrug-resistant bacteria but also heals wounds infected by bacteria in vivo and, most importantly, effectively evades bacterial resistance development. NGA-Mn exhibits up to 25-fold higher cytocompatibility to human cells than its minimum bacterial inhibitory concentration, demonstrating its potential as a next-generation antibacterial agent. Experimental findings suggest that NGA-Mn acts on the outer side of the bacterial cell membrane via a multimolecular collective binding, blocking vital functions in both Gram-positive and Gram-negative bacteria. The results underscore the potential of single-atom engineering toward potent antibiotics, offering simultaneously a long-sought solution for evading drug resistance development while being cytocompatible to human cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.