Evidence map›Paper›PMID 39307923›Full record

ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025

Risk of suicide in association with major depressive disorder among patients with dementia: a populationbased nested case-control study.

Jiun-Yi Wang, Yi-Ting Hsu, Chih-Yuan Lin, Chien-Hui Liu, Kun-Chia Chang, Chih-Ching Liu

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Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Jiun-Yi WangDepartment of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Yi-Ting HsuDepartment of Neurology, China Medical University Hospital, Taichung, Taiwan. Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan. College of Medicine, China Medical University, Taichung, Taiwan.
Chih-Yuan LinInstitute of Health and Welfare Policy, School of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan. Department of Neurology, Taipei City Hospital, Linsen Chinese Medicine Branch, Taipei City, Taiwan.
Chien-Hui LiuInstitute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei City, Taiwan. Division of Emergency Medical Service, New Taipei City Fire Department, New Taipei City, Taiwan.
Kun-Chia ChangJianan Psychiatric Center, Ministry of Health and Welfare, Tainan, Taiwan. Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chih-Ching LiuDepartment of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan. Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.

Funding

Asia University/China Medical University Hospital Joint Research Program ASIA-120-CMUH-19National Science and Technology Council 111-2410-H468-003-MY2; NSTC 111-2410-H-227-019-MY2National Science and Technology Council MOST 111-2410-H-468-003-MY2
6 · The paper itself

Abstract

objectiveThis study aimed to explore the association between major depressive disorder (MDD) and suicide risk in patients with dementia.

methodsA cohort of 625,218 individuals aged = 40 years with dementia was identified from Taiwan's National Health Insurance Research Database (NHIRD) between 2007 and 2018. After excluding prevalent cases in 2007, a nested case-control study enrolling 1,256 suicide cases and 5,022 matched controls was conducted. The frequencies of MDD-related outpatient or inpatient visits over a 7-year period preceding the event dates were calculated and analyzed for association using conditional logistic regression.

resultsDementia comorbid with MDD was associated with increased suicide risk (adjusted OR [AOR]: 2.67), particularly in individuals with = 1.0 MDD episodes per year (AOR: 2.85). A similar association was observed only in individuals aged = 65 years and males, with a pronounced risk of suicide in those experiencing = 1.0 MDD episodes per year (AOR: 3.08 for individuals aged = 65 years; AOR: 3.28 for males). Conversely, the risk increase was evident with > 1.0 MDD episodes per year in those aged < 65 years (AOR: 3.04) and females (AOR: 2.45).

conclusionMDD is associated with suicide risk in patients with dementia. The strength of this association possibly varies with age and gender.

Indexed as

DementiaMajor Depressive DisorderSuicideAdultAgedAged, 80 and overCase-Control StudiesComorbidityFemaleHumansMaleMiddle AgedRisk FactorsSex FactorsTaiwanDementiamajor depressive disordernested case-control studysuicide

Identifiers

PMID39307923
PMCPMC12679695

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