Evidence map›Paper›PMID 39307894›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024

Exposure to air pollution might decrease bone mineral density and increase the prevalence of osteoporosis: a Mendelian randomization study.

Junji Du, Hongbin Cui, Yingjian Zhao, Hongbo Xue, Juwen Chen

Erratum issuedAbstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Maternal Exposure to Wood-Smoke-Derived PMInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. TheInternational journal of burns and trauma · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Junji DuThe Fourth Central Clinical College, Tianjin Medical University, Tianjin, China.
Hongbin CuiThe Fourth Central Clinical College, Tianjin Medical University, Tianjin, China.
Yingjian ZhaoThe Fourth Central Clinical College, Tianjin Medical University, Tianjin, China.
Hongbo XueThe Fourth Central Clinical College, Tianjin Medical University, Tianjin, China.
Juwen ChenDepartment of Orthopedics, The Fourth Central Clinical College, Tianjin Medical University, Tianjin, China. chenjuwen1117@126.com.ORCID http://orcid.org/0000-0003-2825-6537

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study, using Mendelian randomization, reveals a causal link between nitrogen oxides and PM2.5 exposure and reduced total-body bone mineral density, highlighting a potential risk factor for osteoporosis. The findings emphasize the importance of targeted interventions in populations exposed to higher air pollution.

introductionWith the aging of the population, the prevalence of osteoporosis is escalating. Observational studies suggest that air pollution might diminish bone mineral density (BMD), contributing to elevating the likelihood of developing osteoporosis.

methodsEmploying a two-sample Mendelian randomization (MR) analysis, our study aimed to explore the potential causal effect of air pollution on total-body BMD. We utilized extensive publicly available data from genome-wide association studies (GWAS) in this research. Inverse variance weighting was selected for the primary effect estimation, complemented by additional approaches such as the weighted median, MR-Egger, simple mode, and weighted mode. Sensitivity analyses were then conducted to evaluate heterogeneity, pleiotropy, and the presence of outliers.

resultsIn the MR analysis, our findings revealed causal associations between nitrogen oxides (β =  - 0.55, 95% CI - 0.90 to - 0.21, P = 0.002) and particulate matter (PM) 2.5 (β =  - 0.33, 95% CI - 0.59 to - 0.08, P = 0.010) and a reduction in total-body BMD. No significant associations were detected between PM2.5-10, PM10, nitrogen dioxide, and total-body BMD (P > 0.05). Rigorous sensitivity analyses verified the stability of these significant results.

conclusionsOur study illustrates that exposure to nitrogen oxides and PM2.5 may lead to a decrease in total-body BMD, increasing the risk of osteoporosis. This evidence holds crucial implications for policymakers and healthcare providers, as it can provide targeted interventions for the prevention of osteoporosis.

Indexed as

Air PollutionBone DensityEnvironmental ExposureGenome-Wide Association StudyMendelian Randomization AnalysisOsteoporosisParticulate MatterAir PollutantsHumansNitrogen OxidesPolymorphism, Single NucleotidePrevalenceRisk FactorsAir PollutantsNitrogen OxidesParticulate MatterAir pollutionBone mineral densityCausal associationGWASMendelian randomizationOsteoporosis

Identifiers

PMID39307894

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.