Evidence map›Paper›PMID 39307581›Full record

ReviewTrends in immunology2024

Setting the tone: nociceptors as conductors of immune responses.

Pavel Hanč, Marie-Angèle Messou, Jainu Ajit, Ulrich H von Andrian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Immune functions of the esophagus.The Journal of allergy and clinical immunology · 2026
    Review
  5. Review
  6. Review
  7. The oesophagus as an immune organ.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  8. Nano-Anesthetics Regulate Neuro-Immune Interaction for Treating Neuropathic Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pavel HančDepartment of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
Marie-Angèle MessouDepartment of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
Jainu AjitDepartment of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
Ulrich H von AndrianDepartment of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. Electronic address: uva@hms.harvard.edu.

Funding

Intravascular Immune Surveillance by Anti-viral T CellsR01AI155865 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2021 to 2025
$3.2M
Neutrophil Dynamics in Nasal MucosaR01AI175379 · NIAID · HARVARD MEDICAL SCHOOL · PI ULRICH H VON ANDRIAN · 2023 to 2026
$2.7M
NIAID NIH HHS R01 AI155865NIAID NIH HHS R01 AI175379
6 · The paper itself

Abstract

Nociceptors have emerged as master regulators of immune responses in both homeostatic and pathologic settings; however, their seemingly contradictory effects on the functions of different immune cell subsets have been a source of confusion. Nevertheless, work by many groups in recent years has begun to identify patterns of the modalities and consequences of nociceptor-immune system communication. Here, we review recent findings of how nociceptors affect immunity and propose an integrated concept whereby nociceptors are neither inherently pro- nor anti-inflammatory. Rather, we propose that nociceptors have the role of a rheostat that, in a context-dependent manner, favors tissue homeostasis and fine-tunes immunity by preventing excessive histotoxic inflammation, promoting tissue repair, and potentiating anticipatory and adaptive immune responses.

Indexed as

NociceptorsAdaptive ImmunityAnimalsHomeostasisHumansImmunityInflammationinflammationneuroimmunologynociceptorstissue homeostasis

Identifiers

PMID39307581
PMCPMC11493364

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.