Evidence map›Paper›PMID 39307570›Full record

ArticleWorld journal of surgery2024

The clinicopathological landscape of thyroid cancer in South Africa-A multi-institutional review.

Wilhelmina Conradie, Thifhelimbilu Luvhengo, Jeanne Adele Lübbe, Amir Afrogheh, Aneldi Bestbier, Mirza Bhuiyan, Ifongo Bombil, Sharon Raye Čačala, Lydia Cairncross, Chanel Changfoot and 12 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Wilhelmina ConradieDepartment of Surgery, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa.ORCID 0000-0002-9220-331X
Thifhelimbilu LuvhengoDepartment of Surgery, University of Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-2901-1809
Jeanne Adele LübbeDepartment of Surgery, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa.ORCID 0000-0001-8397-8685
Amir AfroghehDepartment of Oral and Maxillofacial Pathology, University of the Western Cape and National Health Laboratory Service (NHLS), Cape Town, South Africa.ORCID 0000-0001-5818-7945
Aneldi BestbierPort Elizabeth Hospital Complex, Walter Sisulu University, Gqeberha, South Africa.ORCID 0009-0003-2815-0182
Mirza BhuiyanDepartment of General Surgery, Mankweng Academic Hospital, University of Limpopo, Pretoria, South Africa.ORCID 0000-0002-0406-6563
Ifongo BombilDepartment of Surgery, University of Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-4819-0785
Sharon Raye ČačalaDepartment of Surgery, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa.ORCID 0000-0003-0713-3925
Lydia CairncrossDepartment of Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-5368-9882
Chanel ChangfootDepartment of Surgery, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa.
Jenny EdgeUniversity of Witwatersrand, Charlotte Maxeke Hospital, Johannesburg, South Africa.ORCID 0000-0003-3005-7254
Brandon S JacksonKalafong Provincial Tertiary Hospital, University of Pretoria, Pretoria, South Africa.ORCID 0000-0001-8994-8575
Hansjörg S JehlePort Elizabeth Hospital Complex, Walter Sisulu University, Gqeberha, South Africa.
Lusanda JonasPietersburg Hospital, University of Limpopo, Polokwane, South Africa.
Mpoyi Ruphin LukusaGrey's Hospital, University of KwaZulu-Natal, Pietermaritzburg, South Africa.ORCID 0000-0002-7188-163X
Malose MakgokaDepartment of General Surgery, Steve Biko Academic Hospital, Pretoria, South Africa.ORCID 0009-0000-8783-8647
Lindi MartinDepartment of Surgery, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa.ORCID 0000-0003-2887-647X
Daniel NelDivision of General Surgery, Department of Surgery, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-3265-1049
Mohamed Quraish PatelDepartment of Surgery, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa.ORCID 0000-0001-9961-4798
Nosisa Thabile SishubaDepartment of Surgery, University of Witwatersrand, Johannesburg, South Africa.ORCID 0000-0003-2333-8867
Rubina RazackNational Health Laboratory Service, Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa.ORCID 0000-0002-2981-4724
Karin BaatjesDepartment Surgical Sciences, University of Stellenbosch, Cape Town, South Africa.ORCID 0000-0001-8432-8844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn South Africa (SA), data on the incidence of thyroid cancer is limited. Papillary thyroid carcinoma is by far the most common malignancy in developed countries; however, a preponderance of follicular thyroid cancer in developing countries, despite iodized salt, has been observed. The aim of this study was to describe the national landscape of thyroid cancer in SA with reference to pathological subtypes, surgical outcomes, and treatments offered.

methodsA multi-institutional retrospective review of thyroid cancer patients operated on between January 2015 and December 2019 was performed. Public hospitals with associated academic institutions were included. Data were collected from theater registers, pathology, and radiology records. Statistical analysis was done to determine intergroup significance.

resultsA total of 464 thyroid cancer cases from 13 centers across five SA provinces were identified. Most patients presented with a mass (67%). Ultrasound was performed in 82% of patients, and 16.3% underwent surgery without pre-operative cytology. Of the histologically confirmed thyroid cancers, 61.8% were papillary and 22.1% follicular thyroid cancer. There was a significant association between subtype and geographical area, and T-stage and operation performed. Surgical complication rates included hematoma in 1.8%, post-operative hypocalcemia in 28.7%, and recurrent laryngeal nerve injury in 3.5%.

conclusionThis first national review describes the landscape of thyroid cancer in SA, revealing considerable differences compared to international studies. It provides valuable insight into the unique South African experience with this disease. In addition, this study serves as an impetus towards a prospective national registry with real-world data informing contextualized guidelines.

Indexed as

Adenocarcinoma, FollicularThyroidectomyThyroid NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingPostoperative ComplicationsRetrospective StudiesSouth AfricaThyroid Cancer, PapillaryYoung AdultAfricalow‐to‐middle income countrySouth Africathyroidthyroid cancer

Identifiers

PMID39307570
PMCPMC11619748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.