Evidence map›Paper›PMID 39307450›Full record

ArticleExperimental eye research2024

Bax expression impacts postnatal retinal vascular development and hyperoxia sensitivity.

Nader Sheibani, Yanzhi Sang, Shoujian Wang, Christine M Sorenson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The effect of plasma exosomal microRNA- 148a- 3p on the CD4Archives of dermatological research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nader SheibaniDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Yanzhi SangDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Shoujian WangDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Christine M SorensonMcPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: cmsorenson@wisc.edu.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
VEGF Antagonism and Resistance to Neovascular AMDR01EY030076 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2020 to 2023
$1.5M
Implementing a novel multimode 3D retinal imaging system to investigate metabolism and vascular disruptions in diabetic retinopathyR15EY031533 · NEI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI RANJI, MAHSA · 2020 to 2020
$445k
Bcl-2, Subretinal Scar Formation and Neovascular AMDR21EY034646 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2023 to 2023
$428k
NCI NIH HHS P30 CA014520NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY030076NEI NIH HHS R15 EY031533NEI NIH HHS R21 EY034646
6 · The paper itself

Abstract

Apoptosis plays prominent roles during organ development, maturation and homeostasis. In the retina, Bcl-2 family members function through the intrinsic cell death pathway with vital roles during vascular development and hyperoxia-mediated vessel obliteration during oxygen induced ischemic retinopathy (OIR). Bim, a BH3 only protein Bcl-2 family member, binds and activates Bax and/or Bak to facilitate apoptosis. In some systems deletion of both Bax and Bak are required to prevent cell loss, such as regression of ocular hyaloid vasculature. We previously showed Bim expression significantly impacts normal retinal vascular development and sensitivity to hyperoxia. Mice deficient in Bim (Bim

Indexed as

Apoptosisbcl-2-Associated X ProteinHyperoxiaMice, Inbred C57BLMice, KnockoutRetinal VesselsAnimalsAnimals, NewbornBcl-2-Like Protein 11Disease Models, AnimalMiceOxygenPericytesBax protein, mousebcl-2-Associated X ProteinBcl2l11 protein, mouseBcl-2-Like Protein 11Oxygen

Identifiers

PMID39307450
PMCPMC11532006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.