Evidence map›Paper›PMID 39306724›Full record

ArticleJapanese journal of clinical oncology2025

Laparoscopic versus open colectomy for locally advanced colon cancer in obese patients: a nationwide, multicenter, propensity score-based analysis of short- and long-term outcomes.

Kentaro Nakajima, Tomonori Akagi, Yohei Kono, Hidefumi Shiroshita, Tetsuji Ohyama, Shuji Saito, Yoshinori Kagawa, Takatoshi Nakamura, Shinobu Ohnuma, Yutaka Kojima and 6 more

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Japanese journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Early post-operative outcomes in adults undergoing minimally invasive versus open emergency colorectal surgery: A retrospective cohort study of the ACS-NSQIP 2016-2022.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kentaro NakajimaDepartment of Surgery, NTT Medical Center Tokyo, Tokyo, Japan.ORCID 0000-0003-4048-2895
Tomonori AkagiGastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu, Oita, Japan.ORCID 0000-0002-0722-0343
Yohei KonoGastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu, Oita, Japan.ORCID 0000-0002-5285-9998
Hidefumi ShiroshitaGastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Tetsuji OhyamaBiostatistics Center, Kurume University, Fukuoka, Japan.
Shuji SaitoDivision of Surgery, Gastrointestinal Center, Yokohama Shin-Midori General Hospital, Yokohama, Japan.
Yoshinori KagawaDepartment of Gastroenterological Surgery, Osaka International Cancer Center, Osaka, Japan.ORCID 0000-0001-6876-4507
Takatoshi NakamuraDepartment of Colorectal Surgery, Dokkyo Medical University, Shimotsuga, Japan.
Shinobu OhnumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yutaka KojimaDepartment of Coloproctological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Masafumi InomataGastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Seiichiro YamamotoDepartment of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan.
Takeshi NaitohDepartment of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Japan.ORCID 0000-0003-4169-6334
Yoshiharu SakaiDepartment of Surgery, Osaka Red Cross Hospital, Osaka, Japan.
Masahiko WatanabeDepartment of Surgery, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Japan Society of Laparoscopic Colorectal Surgery

Funding

Japanese Foundation for Research and Promotion of EndoscopyJapan Society of Clinical Oncology
6 · The paper itself

Abstract

objectiveThis study evaluated the short-and long-term outcomes of laparoscopic colectomy versus open surgery in obese patients (body mass index ≥25 kg/m2) with locally advanced colon cancer to ascertain the non-inferiority of laparoscopic surgery to open surgery.

methodsIn this large cohort study (UMIN-ID: UMIN000033529), we retrospectively reviewed prospectively collected data from consecutive patients who underwent laparoscopic or open surgery for pathological stage II-III colon cancer between 2009 and 2013. A comparative analysis was performed after propensity score matching between the laparoscopic and open surgery groups. The primary endpoint was the 3-year relapse-free survival (RFS).

resultsWe identified 1575 eligible patients from 46 institutions. Each group comprised 526 propensity score-matched patients. Comparing the laparoscopic versus open surgery group, laparoscopic surgery was significantly associated with increased median operating time (225 vs. 192.5 min; P < .0001) and decreased median estimated blood loss (20 vs. 140 ml; P < .0001). Lymph node retrieval (20 vs. 19; P = 0.4392) and postoperative complications (4.6% vs. 5.7%; P = 0.4851) were similar, postoperative hospital stay was shorter (10 vs. 12 days; P < .0001), and the 3-year RFS rates were similar (82.8 vs. 81.2%). The hazard ratio (HR) for relapse-free survival for laparoscopic versus open surgery was 0.927 (90% confidence interval [CI], 0.747-1.150, one-sided P for non-inferiority = .001), indicating that for obese patients with colon cancer, laparoscopic surgery was non-inferior to open surgery.

conclusionLaparoscopic surgery in obese patients with colon cancer offers advantages in terms of short-term outcomes and no disadvantages in terms of long-term outcomes.

Indexed as

ColectomyColonic NeoplasmsLaparoscopyObesityPropensity ScoreAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansLength of StayMaleMiddle AgedNeoplasm StagingPostoperative Complicationsbody mass indexcolonic neoplasmlaparoscopy

Identifiers

PMID39306724
PMCPMC11708209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.