ArticleBMC veterinary research2024
Efficacy of zinc nanoparticle supplementation on ruminal environment in lambs.
Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The influence of zinc oxide utilization in ruminants: A systematic review and meta-analysis.Veterinary and animal science · 2026Article
- Effects of Nano Zinc Oxide Supplementation on Oxidative Stress and Selected Metabolic Parameters During the Transition Period in Lacaune Ewes.Veterinary medicine and science · 2026Article
- Comparative effects of different zinc sources and inclusion levels on growth performance, antioxidant status, and meat quality in fattening lambs.Tropical animal health and production · 2026Article
- Microbial Synthesis of Nano Trace Minerals: A Comprehensive Review on Synthesis, Characterization, Biological Effects and Applications in Farm Animals.Biological trace element research · 2026Review
- Applications of Nanotechnology in Ruminant Animal Production: Advances, Challenges, and Future Prospects.Nanomaterials (Basel, Switzerland) · 2025Review
- Chicory modulates the rumen environment in lambs with endoparasites.Scientific reports · 2025Article
- Productive Performance and Some Biochemical Indices of Ossimi Ewes and Their Lambs to Dietary Inclusion of Selenium, Zinc Nanoparticles, or Their Combination.Animals : an open access journal from MDPI · 2025Article
- Revolutionizing Veterinary Medicine: The Role of Nanoparticles in Advancing Animal Health, Nutrition and Disease Management.Veterinary medicine and science · 2025Review
- Zinc Oxide Nanoparticles as Next-Generation Feed Additives: Bridging Antimicrobial Efficacy, Growth Promotion, and Sustainable Strategies in Animal Nutrition.Nanomaterials (Basel, Switzerland) · 2025Review
- Effect of zinc oxide nanoparticle supplementation on parasite infection and rumen environment of grazing lambs.Frontiers in veterinary science · 2025Article
- The effects of short-term intake of dietary zinc nanoparticles on plasma mineral and antioxidant status, nutrient digestibility, and intestinal microbiota in lambs.Frontiers in veterinary science · 2025Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundZinc nanoparticles (NPs) are characterized by high bioavailability, small size, and high absorbability. The purpose of this experiment was to determine the effect of Zn-NP feed supplementation on ruminal fermentation, microbiota, and histopathology in lambs. In vitro (24 h), short-term (STE, 28 d), and long-term (LTE, 70 d) experiments were performed. The lambs in STE were fed a basal diet (BD) composed of 350 g/d ground barley and 700 g/d meadow hay (Control), BD enriched with ZnO-NPs (80 mg Zn/kg of diet, ZnO-NPs), and BD enriched with Zn phosphate-based NPs (80 mg Zn/kg of diet, ZnP-NP). The in vitro gas production technique was used in incubated rumen fluid from STE. The lambs in LTE were fed BD (Control), BD enriched with ZnO-NPs (40 mg Zn/kg of diet, ZnO-NP40), BD enriched with ZnO-NPs (80 mg Zn/kg of diet, ZnO-NP80) and BD enriched with ZnO (80 mg Zn/kg of diet, ZnO-80).
resultsAfter 24 h of incubation, dry matter digestibility was higher for ZnO-NP and ZnP-NP substrates than the control in an in vitro experiment (P < 0.001). The total bacterial population in the STE was lower (P < 0.001) in the ZnP-NP group than in the control and ZnO-NP groups, but the protozoan populations were not significantly different. The ammonia-N concentration in LTE was lowest in the ZnO-NP80 group (P = 0.002), but the activities of carboxymethyl cellulase (P < 0.001) and xylanase (P = 0.002) were higher in the ZnO-NP40, ZnO-NP80, and ZnO-80 groups than in the control group. Morphological observation after STE and LTE revealed histological changes (e.g. inflammation of the epithelium or edema of the connective tissue) in the rumen of lambs.
conclusionZn-NP supplementation up to 70 d improved feed-use efficiency and influenced ammonia-N concentration and activities of hydrolases in the rumen. The active ruminal fermentation affected the health of the ruminal papillae and epithelium in the lambs, regardless of the application's form, dose, or duration. However, by affecting rumen microbial fermentation, Zn-NPs could alter fermentation patterns, thereby increasing the capacity of host rumen epithelial cells to transport short-chain fatty acids.
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