Evidence map›Paper›PMID 39306320›Full record

ArticleThe Journal of pediatrics2025

Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study.

Lindsay M Thomson, Sierra Niemiec, Christopher A Mancuso, Ludmila Khailova, Eiman Ali, Aneesa Syed, Kelly R Wolfe, Jack Zakrzewski, Matthew Stone, Robert Hyslop and 2 more

Abstract read
In one paragraph

Article in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lindsay M ThomsonDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Sierra NiemiecDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Christopher A MancusoDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Ludmila KhailovaDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Eiman AliDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Aneesa SyedDepartment of Pathology & Laboratory Medicine, Children's Hospital Colorado, Aurora, CO.
Kelly R WolfeDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Jack ZakrzewskiDeparment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.
Matthew StoneDeparment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.
Robert HyslopHeart Institute, Children's Hospital Colorado, Aurora, CO.
Benjamin S FrankDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Jesse A DavidsonDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address: jesse.davidson@childrenscolorado.org.

Funding

Metabolic profiling and comprehensive metabolic pathway mapping: a systems biology approach to cardiovascular failure and organ injury following infant congenital heart disease surgeryR01HL156936 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DAVIDSON, JESSE · 2021 to 2025
$3.1M
Colorado StARR Program in Medicine and Pediatrics (CSPMP)R38HL143511 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Steven Herbert Abman, Peter N. Buttrick · 2020 to 2026
$2.7M
Pulmonary Vascular Development in Single Ventricle Heart Disease: A Longitudinal Biomarker ApproachK23HL163490 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Benjamin S Frank · 2023 to 2026
$745k
NHLBI NIH HHS K23 HL163490NHLBI NIH HHS R01 HL156936NHLBI NIH HHS R38 HL143511
6 · The paper itself

Abstract

This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.

Indexed as

BiomarkersExtracorporeal Membrane OxygenationHeart Defects, CongenitalProteomeCardiac Surgical ProceduresCase-Control StudiesFemaleHumansInfant, NewbornMaleBiomarkersProteomecardiac surgerycardiopulmonary bypassECMOerythropoietinprotein biomarkersproteomics

Identifiers

PMID39306320
PMCPMC11645209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.