Evidence map›Paper›PMID 39305994›Full record

ArticleAmerican journal of obstetrics & gynecology MFM2024

Cesarean delivery, labor duration, and mothers' mortality risk over 50 years of follow-up.

Susanna D Mitro, Rajeshwari Sundaram, Sonia M Grandi, Stefanie N Hinkle, James L Mills, Pauline Mendola, Sunni L Mumford, Yan Qiao, Anokhi Cifuentes, Cuilin Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of obstetrics & gynecology MFM, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Susanna D MitroEpidemiology Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (Mitro, Mills, Qiao, Cifuentes, and Grantz); Kaiser Permanente Northern California Division of Research, Oakland, CA (Mitro).
Rajeshwari SundaramBiostatistics and Bioinformatics Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (Sundaram).
Sonia M GrandiChild Health Evaluative Sciences, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada (Grandi); Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada (Grandi).
Stefanie N HinkleDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (Hinkle, Mumford, and Schisterman).
James L MillsEpidemiology Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (Mitro, Mills, Qiao, Cifuentes, and Grantz); Kaiser Permanente Northern California Division of Research, Oakland, CA (Mitro).
Pauline MendolaDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY (Mendola).
Sunni L MumfordDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (Hinkle, Mumford, and Schisterman).
Yan QiaoEpidemiology Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (Mitro, Mills, Qiao, Cifuentes, and Grantz); The Prospective Group, Inc., Fairfax, VA (Qiao and Cifuentes).
Anokhi CifuentesEpidemiology Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (Mitro, Mills, Qiao, Cifuentes, and Grantz); The Prospective Group, Inc., Fairfax, VA (Qiao and Cifuentes).
Cuilin ZhangBia-Echo Asia Centre for Reproductive Longevity & Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore (Zhang); Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore (Zhang).
Enrique F SchistermanDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (Hinkle, Mumford, and Schisterman).
Katherine L GrantzEpidemiology Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (Mitro, Mills, Qiao, Cifuentes, and Grantz); Kaiser Permanente Northern California Division of Research, Oakland, CA (Mitro). Electronic address: katherine.grantz@nih.gov.

Funding

University of California, San Francisco/Kaiser Permanente Northern California Division of Research Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12 ProgramK12AR084219 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi, CYNTHIA C HARPER · 2023 to 2026
$3.1M
Intramural NIH HHS Z99 HD999999NIAMS NIH HHS K12 AR084219NICHD NIH HHS HHSN275200800002I
6 · The paper itself

Abstract

backgroundPregnancy complications have been recognized as a window to future health. Though cesarean delivery is common, it is unknown whether labor duration and mode of delivery are associated with maternal long-term mortality.

objectiveTo examine whether labor duration and mode of delivery were associated with all-cause and cause-specific mortality. STUDY

designParticipants were mothers from the multisite Collaborative Perinatal Project (CPP) cohort (1959-1966; n=43,646, limited to last CPP delivery). We ascertained all-cause and specific causes of death as of 2016 via linkage to the National Death Index and Social Security Death Master File. Hazard ratios (HR) testing mode of delivery and labor duration were estimated using Cox proportional hazards models adjusted for demographic and clinical characteristics. We further stratified analyses by parity.

resultsAmong participants with a recorded delivery mode, 5.9% (2486/42,335) had a cesarean delivery. Participants who had a cesarean were older (26.9 vs 24.3 years), with higher body mass index (24.0 vs 22.7 kg/m

conclusionIn a historic United States cohort with a low cesarean delivery rate, cesarean delivery was an indicator for subsequent increased mortality risk, particularly related to cardiovascular disease and diabetes. Future studies with long-term follow-up are warranted given the current high prevalence of cesarean delivery.

Indexed as

Cesarean SectionAdultCause of DeathCohort StudiesDelivery, ObstetricFemaleFollow-Up StudiesHumansLabor, ObstetricMaternal MortalityMiddle AgedParityPregnancyProportional Hazards ModelsRisk FactorsTime FactorsCollaborative Perinatal Projectepidemiologymaternal mortalitymode of delivery

Identifiers

PMID39305994
PMCPMC11563887

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.