Evidence map›Paper›PMID 39305791›Full record

ArticleSchizophrenia research2024

Arousal responses to personal space intrusions in psychotic illness: A virtual reality study.

Baktash Babadi, Katherine Dokholyan, Nicole R DeTore, Roger B H Tootell, Rachel F Sussman, Sarah L Zapetis, Daphne J Holt

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Article in Schizophrenia research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Baktash BabadiDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Katherine DokholyanDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Nicole R DeToreDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Roger B H TootellHarvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; The Athinoula A. Martinos Center for Biomedical Imaging, 149 13th Street, Charlestown, MA 02129, USA.
Rachel F SussmanDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Sarah L ZapetisDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Daphne J HoltDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; The Athinoula A. Martinos Center for Biomedical Imaging, 149 13th Street, Charlestown, MA 02129, USA. Electronic address: dholt@mgh.harvard.edu.

Funding

Neural mechanisms of social distance in psychosisR01MH109562 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HOLT, DAPHNE J · 2016 to 2020
$4.1M
Deficits of the Early Visual System in Schizophrenia, a Combined Psychophysical, Computational, and Neuroimaging ApproachK23MH127508 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BABADI, BAKTASH · 2022 to 2025
$770k
NIMH NIH HHS K23 MH127508NIMH NIH HHS R01 MH109562
6 · The paper itself

Abstract

backgroundPrior studies have found that individuals with schizophrenia often have an enlarged "personal space". However, the neurocognitive mechanisms underlying this consistent finding remain unknown.

methodsThe well-validated Stop Distance Procedure was used to measure the personal space preferences of individuals with psychotic disorders (PD, N = 22) and demographically-matched healthy controls (HC, N = 20) in response to human and virtual (avatar) intruders. Physiological arousal and subjective discomfort were measured during intrusions into personal space and modeled across different interpersonal distances. Additionally, participants were interviewed to assess their subjective awareness of their personal space preferences.

resultsPersonal space measurements with humans and avatars were highly correlated and reliable over repeated trials, and influenced by the displayed emotion and gender of the intruders, in both groups. The PD group exhibited a larger personal space than the HC group (all p < 0.028), and the size of personal space with avatar intruders was significantly correlated with positive symptom severity in the PD subjects. Moreover, the magnitude of arousal responses to personal space intrusions was proportional to a power (exponent) of the distance between subjects and intruders, with a significantly smaller exponent in the PD (compared to the HC) for both human (p = 0.026) and avatar (p = 0.011) intruders, indicating a less steep function. Lastly, much of the participants' qualitative impressions of their personal space behaviors were consistent or correlated with the quantitative findings, reflecting some awareness of the determinants of personal space.

conclusionsThese findings reveal both intact and altered aspects of personal space regulation in psychotic disorders, and the potential utility of personal space measurements, given their high reliability, to serve as objective targets of interventions.

Indexed as

ArousalPersonal SpacePsychotic DisordersVirtual RealityAdultFemaleGalvanic Skin ResponseHumansMaleMiddle AgedSchizophreniaYoung AdultPersonal spacePsychotic disordersSchizophreniaSelf-disturbanceVirtual reality

Identifiers

PMID39305791
PMCPMC12323404

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