Evidence map›Paper›PMID 39305519›Full record

ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2024

Introducing a new severity specifier for schizophrenia: conceptual framework and clinical implications.

Ary Gadelha, Renan M Biokino, Pedro Lorencetti, Nicolas A Crossley, Daniela Bordini, Raffael Massuda

Abstract read
In one paragraph

Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ary GadelhaDepartamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil. Programa de Esquizofrenia, EPM/UNIFESP, São Paulo, SP, Brazil. Laboratório Interdisciplinar de Neurociências Clínicas, Departamento de Psiquiatria, EPM/UNIFESP, São Paulo, SP, Brazil.
Renan M BiokinoDepartamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil. Programa de Esquizofrenia, EPM/UNIFESP, São Paulo, SP, Brazil.
Pedro LorencettiDepartamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil. Programa de Esquizofrenia, EPM/UNIFESP, São Paulo, SP, Brazil. Laboratório Interdisciplinar de Neurociências Clínicas, Departamento de Psiquiatria, EPM/UNIFESP, São Paulo, SP, Brazil.
Nicolas A CrossleyDepartamento de Psiquiatría, Pontificia Universidad Católica de Chile, Santiago, Chile.
Daniela BordiniAmbulatório de Autismo, UNIFESP, São Paulo, SP, Brazil.
Raffael MassudaDepartamento de Psiquiatria, Universidade Federal do Paraná, Curitiba, PR, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with schizophrenia represent a group heterogeneous in clinical presentation and severity. Although severity has been operationalized in different ways, mostly on a gradient between symptom severity and functional impairment, such approaches are limited in capturing real-world functioning. We suggest adopting the severity model proposed by DSM-5 for autism spectrum disorders. The model defines three levels of severity based on the support required, directly addressing two barriers from previous models: real-world functioning and ease of implementation. Our adapted model includes three new features: first, this severity specifier is global, rather than for each symptom domain; second, the centrality of occupational functioning is emphasized to define the level of support; third, we propose a 1-month timeframe for severity appraisal, standardizing the assessment process. Considering practical utility, we indicate how severity assessment can guide clinical practice towards rehabilitation. Additionally, we outline operational definitions for severity and functioning in schizophrenia, aligned with the premises of our model. Finally, we acknowledge potential limitations, the most relevant being the need for empirical validation. The model is presented to foster discussion. Additional studies will follow to investigate inter-rater reliability and convergent validation with standard measures of symptom and functioning severity.

Indexed as

SchizophreniaSeverity of Illness IndexDiagnostic and Statistical Manual of Mental DisordersHumansPsychiatric Status Rating ScalesReproducibility of ResultsSchizophrenic PsychologyfunctioningPsychosisschizophreniaseverityspecifier

Identifiers

PMID39305519
PMCPMC11773320

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