Evidence map›Paper›PMID 39305468›Full record

ArticleGut microbes

Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice.

Shenhai Gong, Yunong Zeng, Ze Wang, Yanru Li, Rong Wu, Lei Li, Hongbin Hu, Ping Qin, Zhichao Yu, Xintao Huang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Research progress in the field of drug-induced liver injury in the year 2024].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shenhai GongSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Yunong ZengDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ze WangDepartment of Critical Care Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yanru LiDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Rong WuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Lei LiHenan Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine and Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hongbin HuDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ping QinSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Zhichao YuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Xintao HuangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Peiheng GuoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Hong YangDepartment of Critical Care Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yi HeDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Zhibin ZhaoMedical Research Institute, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China.
Weidong XiaoDepartment of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xiaoshan ZhaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Lei GaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Shumin CaiDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhenhua ZengDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear. Our study reveals that the gender-specific differences in susceptibility to APAP-induced hepatotoxicity are due to differences in the gut microbiota. Through microbial multi-omics and cultivation, we observed increased gut microbiota-derived deguelin content in both women and female mice. Administration of deguelin was capable of alleviating hepatotoxicity in APAP-treated male mice, and this protective effect was associated with the inhibition of hepatocyte oxidative stress. Mechanistically, deguelin reduced the expression of thyrotropin receptor (TSHR) in hepatocytes with APAP treatment through direct interaction. Pharmacologic suppression of TSHR expression using ML224 significantly increased hepatic glutathione (GSH) in APAP-treated male mice. These findings suggest that gut microbiota-derived deguelin plays a crucial role in reducing APAP-induced hepatotoxicity in female mice, offering new insights into therapeutic strategies for DILI.

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryGastrointestinal MicrobiomeRotenoneAnimalsFemaleGlutathioneHepatocytesLiverMaleMiceMice, Inbred C57BLOxidative StressAcetaminophendeguelinGlutathioneRotenonedeguelinDILIgender variabilitygut microbiota

Identifiers

PMID39305468
PMCPMC11418218

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.