Evidence map›Paper›PMID 39305434›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2024

The Leptospira interrogans proteome's response to zinc highlights the potential involvement of this metal in translational-machinery and virulence.

Amanda Silva Hecktheuer, Cassia Moreira Santos, Fabienne Antunes Ferreira, Angela Silva Barbosa, Lourdes Isaac, Marilis Valle Marques, Ricardo Ruiz Mazzon

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda Silva HecktheuerDepartment of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Av. Delfino Conti, S/N-Trindade, Florianópolis, SC, 88040-900, Brazil.ORCID http://orcid.org/0000-0002-0541-9666
Cassia Moreira SantosLaboratory of Bacteriology, Butantan Institute, Av. Vital Brasil, 1500 - Butantan, São Paulo, SP, 05503-900, Brazil.ORCID http://orcid.org/0000-0002-8661-9212
Fabienne Antunes FerreiraDepartment of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Av. Delfino Conti, S/N-Trindade, Florianópolis, SC, 88040-900, Brazil.ORCID http://orcid.org/0000-0002-6444-6007
Angela Silva BarbosaLaboratory of Bacteriology, Butantan Institute, Av. Vital Brasil, 1500 - Butantan, São Paulo, SP, 05503-900, Brazil.ORCID http://orcid.org/0000-0002-6458-9489
Lourdes IsaacDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1730, São Paulo, SP, 05508-000, Brazil.ORCID http://orcid.org/0000-0002-7746-8942
Marilis Valle MarquesDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1374, São Paulo, SP, 05508-900, Brazil.ORCID http://orcid.org/0000-0003-1542-8221
Ricardo Ruiz MazzonDepartment of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Av. Delfino Conti, S/N-Trindade, Florianópolis, SC, 88040-900, Brazil. ricardo.mazzon@ufsc.br.ORCID http://orcid.org/0000-0002-8034-6284

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 401552/2016-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 17/12924-3
6 · The paper itself

Abstract

Leptospires, as motile Gram-negative bacteria, employ sophisticated strategies for efficient invasion and dissemination within their hosts. In response, hosts counteract pathogens through nutritional immunity, a concept involving the deprivation of essential metals such as zinc. Zinc, pivotal in modulating pathogen-host interactions, influences proteins structural, catalytic, and regulatory functions. A comprehensive understanding of how leptospires regulate intracellular zinc availability is crucial for deciphering their survival mechanisms. This study explores the proteomic profile of Leptospira interrogans sv. Copenhageni str. 10A cultivated in Ellinghausen-McCullough-Johnson-Harris medium supplemented with the zinc chelator TPA or ZnCl

Indexed as

Bacterial ProteinsLeptospira interrogansProteomeZincVirulenceBacterial ProteinsProteomeZincNutritional immunityProteomicsSpirochetesZinc homeostasis

Identifiers

PMID39305434

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.