Evidence map›Paper›PMID 39305353›Full record

SynthesisBiochemical genetics2025

Association of MTHFR rs9651118 and TYMS rs2790 Polymorphisms with Risk of Cancers: A Case-Control Study and Meta-analysis.

Weiguang Zhou, Yingxuan Xiao, Yifan Jiang, Aoxiang Zou, Jiangyi Ruan, Xianhong Feng, Jing Li, Bifeng Chen

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Biochemical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Weiguang Zhou *Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070, China.
Yingxuan Xiao *Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070, China.
Yifan JiangInstitute of WUT-AMU, Wuhan University of Technology, Wuhan, Hubei, 430070, China.
Aoxiang ZouInstitute of WUT-AMU, Wuhan University of Technology, Wuhan, Hubei, 430070, China.
Jiangyi RuanDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070, China.
Xianhong FengDepartment of Clinical Laboratory, Wuhan Xinzhou District People's Hospital, Wuhan, Hubei, 431400, China.
Jing LiDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070, China. lij@whut.edu.cn.
Bifeng ChenDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070, China. cbifeng@whut.edu.cn.

Funding

Fundamental Research Funds for the Central Universities WUT: 119-3120624549
6 · The paper itself

Abstract

Recently, rs9651118 in the MTHFR gene and rs2790 in the TYMS gene have been repeatedly studied for their contribution to cancer risk. However, the results remain conflicting rather than conclusive. Therefore, we here conducted a replication case-control study and a meta-analysis to comprehensively examine the contribution of rs9651118 and rs2790 to cancer risk. A total of 1727 patients with colorectal/gastric/liver (787/460/480) cancer and 800 healthy controls were recruited, and the Sanger sequencing was applied to genotype rs9651118 and rs2790. Besides, a total of 23 eligible studies were included in the following meta-analysis. After Bonferroni correction, the results of case-control study suggested that significant associations between rs9651118 and colorectal cancer (CRC) risk, rs9651118 and gastric cancer (GC) risk, and rs2790 and liver cancer (LC) risk were identified in Hubei Chinese population. The results of meta-analysis indicated that after Bonferroni correction, both rs9651118 and rs2790 were significantly associated with total cancer risk especially in Asian population and based on Sanger sequencing method, rs9651118 was significantly associated with breast cancer (BC) risk, and rs2790 was significantly associated with the risk of CRC and GC. In conclusion, the present findings revealed that the MTHFR gene rs9651118 may participate in the risk of total cancer (especially BC) in Asian population, and the TYMS gene rs2790 may be associated with the risk of total cancer (especially CRC) in Asian population and also the risk of GC in total population.

Indexed as

Genetic Predisposition to DiseaseMethylenetetrahydrofolate Reductase (NADPH2)NeoplasmsPolymorphism, Single NucleotideAsian PeopleCase-Control StudiesFemaleHumansMaleMiddle AgedRisk FactorsThymidylate SynthaseMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanThymidylate SynthaseTYMS protein, humanCancer riskGenetic polymorphismMeta-analysisMTHFR geneTYMS gene

Identifiers

PMID39305353

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