Evidence map›Paper›PMID 39305014›Full record

ArticleBiophysical journal2024

Ligand-induced conformational changes in protein molecules detected by sum-frequency generation.

Joshua Salafsky, Patrik K Johansson, Elwy Abdelkader, Gottfried Otting

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joshua SalafskyDepartment of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, California; Skylight Discovery, Inc., Suite 300, Seattle, Washington. Electronic address: joshua.salafsky@ucsf.edu.
Patrik K JohanssonSkylight Discovery, Inc., Suite 300, Seattle, Washington.
Elwy AbdelkaderARC Centre of Excellence for Innovations in Peptide & Protein Science, Research School of Chemistry, Australian National University, Canberra, ACT, Australia.
Gottfried OttingARC Centre of Excellence for Innovations in Peptide & Protein Science, Research School of Chemistry, Australian National University, Canberra, ACT, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the first demonstration of ligand-induced conformational changes in a biological molecule, a protein, by sum-frequency generation (SFG). Constructs of KRas

Indexed as

Protein ConformationLigandsLipid BilayersModels, MolecularProto-Oncogene Proteins p21(ras)LigandsLipid BilayersProto-Oncogene Proteins p21(ras)

Identifiers

PMID39305014
PMCPMC11560303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.