ReviewPeriodontology 20002025
L-PRF in extra-oral wound care.
Review in Periodontology 2000, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Platelet-rich plasma (PRP) versus injectable platelet-rich fibrin (i-PRF): A systematic review across all fields of medicine.Periodontology 2000 · 2025Pooled it
- Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta-analyses.Periodontology 2000 · 2025Pooled it
- Titanium-prepared platelet-rich fibrin enhances alveolar ridge preservation: a randomized controlled clinical and radiographic study.Scientific reports · 2025Trial
- Review
- Stored L-PRF membranes: safety, morphology, tensile properties, and cell viability-an in vitro pilot study.Scientific reports · 2026Article
- Article
- Plasma-Coated Collagen Membranes Gain Barrier Function Through Heat Treatment.Journal of functional biomaterials · 2026Article
- DNA-Inspired Multi-Functional Double-Cross-Linking Self-Healing Hydrogel Promotes the Healing of Diabetic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Evolution of Extended Platelet-Rich Fibrin Membranes for Socket Grafting: Part Two: A Randomized Clinical Trial Comparing These Membranes with Collagen Membranes.Dentistry journal · 2026Article
- Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay.Frontiers in immunology · 2026Article
- Refrigerated storage of L-PRF membranes: anti-bacterial activity, cytokine release, andFrontiers in oral health · 2026Article
- The role of platelet derivatives in regenerative medicine: biological foundations and translational perspectives.Frontiers in cell and developmental biology · 2026Review
- The Evolution of Extended Platelet-Rich Fibrin Membranes for Socket Grafting: Part One: Technical Development of Protocols.Dentistry journal · 2025Article
- Isoliquiritigenin micellar microneedle for pH monitoring and diabetic wound healing.Materials today. Bio · 2025Article
- Tannic acid modified horizontal platelet-rich fibrin membrane with improved mechanical and biological properties for tissue regeneration : Author full names.Scientific reports · 2025Article
- Use of liquid platelet-rich fibrin (liquid PRF) in temporomandibular joint disorders: A narrative review with clinical recommendations.Periodontology 2000 · 2025Review
- Advantages of horizontal centrifugation of platelet-rich fibrin in regenerative medicine and dentistry.Periodontology 2000 · 2025Review
- Extended PRF: Impact of Heat on Gene Expression in Gingival Fibroblasts.International journal of molecular sciences · 2025Article
- Introduction and overview on Autogenous Platelet Concentrates.Periodontology 2000 · 2025Article
- Instructions for the use of L-PRF in different clinical indications.Periodontology 2000 · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukocyte- and platelet-rich fibrin (L-PRF), a by-product of centrifuged autologous whole blood, contains high concentrations of platelets, leukocytes, and fibrin (the latter spontaneously creating a strong 3-D network (a membrane)). L-PRF membranes possess several characteristics essential in wound healing, including a barrier function, an antibacterial and analgesic activity, and the release of growth factors enhancing tissue regeneration and neo-vasculogenesis. This review investigated the role of L-PRF in treating non-responding chronic wounds such as diabetic foot, venous leg ulcers, pressure ulcers, complex wounds, leprosy ulcers (Hansen's Disease), and other demanding wounds. Chronic wounds affect millions worldwide, negatively impacting their quality of life, productivity, and life expectancy while incurring high treatment costs for themselves and private and public health systems. L-PRF has demonstrated clear adjunctive advantages in treating chronic skin wounds, shortening the time to complete wound closure, and improving patient-reported outcome measures (including reducing pain and minimizing the need for analgesics). Also, in other demanding wounds, L-PRF facilitates healing. To help clinicians, this article also proposes recommendations for the use of L-PRF in the treatment of extra-oral wounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.