ArticleAntimicrobial resistance and infection control2024
The genetic relationship between human and pet isolates: a core genome multilocus sequence analysis of multidrug-resistant bacteria.
Article in Antimicrobial resistance and infection control, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Antibiotics in Veterinary Ophthalmology: Resistance, Stewardship, and Emerging Antibiotic-Sparing Strategies.Veterinary ophthalmology · 2026Review
- A Case of Sepsis Caused by ST80 Multidrug-Resistant Enterococcus faecium With Concurrent Klebsiella pneumoniae Infection in a Dog.Veterinary medicine and science · 2026Article
- Genomic epidemiology ofJournal of clinical microbiology · 2026Observational
- Investigating the Sharing ofPathogens (Basel, Switzerland) · 2026Article
- Review
- A One Health Comparative Study of MDRAntibiotics (Basel, Switzerland) · 2025Article
- Evidence of hypervirulent carbapenem-resistant Klebsiella pneumoniae in cats with urinary affections and associated humans in Egypt.Scientific reports · 2025Article
- Prevalence and Risk Factors of Multidrug-ResistantChina CDC weekly · 2025Article
- Exploring AMR and virulence inOne health (Amsterdam, Netherlands) · 2024Article
- Presence of Methicillin-Resistant Staphylococci and Carbapenemase-PositiveVeterinary sciences · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe global increase of multidrug-resistant organisms (MDROs) is one of the most urgent public health threats affecting both humans and animals. The One Health concept emphasizes the interconnectedness of human, animal and environmental health and highlights the need for integrated approaches to combat antimicrobial resistance (AMR). Although the sharing of environments and antimicrobial agents between companion animals and humans poses a risk for MDRO transmission, companion animals have been studied to a lesser extent than livestock animals. This study therefore used core genome multilocus sequence typing (cgMLST) to investigate the genetic relationships and putative transmission of MDROs between humans and pets.
methodsThis descriptive integrated typing study included 252 human isolates, 53 dog isolates and 10 cat isolates collected from 2019 to 2022 at the Charité University Hospital in Berlin, Germany. CgMLST was performed to characterize methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and multidrug-resistant gram-negative bacteria. The genetic diversity of the MDROs of the different host populations was determined and compared based on sequence type and core genome complex type.
resultsWithin this study the majority of samples from pets and humans was genetically distinct. However, for some isolates, the number of allelic differences identified by cgMLST was low. Two cases of putative household transmission or shared source of VR E. faecium and MDR E. coli between humans and pets were documented.
conclusionsThe interaction between humans and their pets appears to play a minor role in the spread of the MDROs studied. However, further research is needed. This study emphasizes the importance of comprehensive molecular surveillance and a multidisciplinary One Health approach to understand and contain the spread of MDROs in human and animal populations.
trial registrationThe study is registered with the German Clinical Trials Register (DRKS00030009).
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