Evidence map›Paper›PMID 39304919›Full record

ArticleJournal of nanobiotechnology2024

Encapsulated lactiplantibacillus plantarum improves Alzheimer's symptoms in APP/PS1 mice.

Fangfang Hu, Qian Gao, Caiyun Zheng, Wenhui Zhang, Ziyi Yang, Shihao Wang, Yanni Zhang, Tingli Lu

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Effects ofFoods (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fangfang HuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
Qian GaoKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
Caiyun ZhengKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
Wenhui ZhangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
Ziyi YangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
Shihao WangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
Yanni ZhangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. yann.zhang@nwpu.edu.cn.
Tingli LuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China. lutinglixinxin@nwpu.edu.cn.

Funding

China Postdoctoral Science Foundation 2021M702633National Natural Science Foundation of China 81803491Natural Science Foundation of Shaanxi Province 2023-JC-YB-290Shaanxi Provincial Key R&D Program 2021SF-106
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is a neurodegenerative disorder that can result in neurotoxicity and an imbalance in gut microbiota. Probiotics have been shown to play an important role in regulating the gut microbiota, but their viability and bioactivity are often compromised as they traverse the gastrointestinal tract, thereby reducing their efficacy and limiting their clinical utility.

resultsIn this work, layer-by-layer (LbL) encapsulation technology was used to encapsulate Lactiplantibacillus plantarum (LP) to improve the above shortcomings. Studies in APPswe/PS1dE9 (APP/PS1) transgenic mice show that LbL-encapsulated LP ((CS/SP)

conclusionOverall, the above evidence suggests that (CS/SP)

Indexed as

Alzheimer DiseaseDisease Models, AnimalGastrointestinal MicrobiomeMice, TransgenicProbioticsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBrainLactiplantibacillus plantarumMaleMicePresenilin-1tau ProteinsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorPresenilin-1tau ProteinsAlzheimer’s diseaseAPP/PS1 miceGut MicrobiomeLactiplantibacillus plantarumLayer-by-layerShort-chain fatty acids

Identifiers

PMID39304919
PMCPMC11414319

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.