Evidence map›Paper›PMID 39304898›Full record

ArticleJournal of cardiothoracic surgery2024

Clinical value of peripheral blood miR-21 and miR-486 combined with CT forearly cancer diagnosis in pulmonary nodulessmoking.

Zheng Wang, Jinfeng Liu, Qiang Liu, Yingchun Ren, Qiang Wang, Qing Tian, Zhijie Li, Huining Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zheng WangDepartment of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China.
Jinfeng LiuDepartment of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China.
Qiang LiuDepartment of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China.
Yingchun RenDepartment of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China.
Qiang WangDepartment of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China.
Qing TianDepartment of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China.
Zhijie LiDepartment of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China.
Huining LiuDepartment of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China. liuhuining1972@163.com.

Funding

Hebei Provincial Health Commission (No. 20230978)
6 · The paper itself

Abstract

purposeThis study aimed to investigate the clinical significance of combining peripheral blood miR-21 and miR-486 with CT for the early cancer diagnosis in pulmonary nodules.

methodsA total of 215 patients diagnosed with isolated pulmonary nodules with a history of smoking were selected as researchsubjects. 30 healthy volunteers with a history of smoking were recruitedas the control group.The selection of subjectswas based on the presence of isolated pulmonary nodules detected on chest CT scans. The training set consisted of 65 patients with lung nodules and 30 healthy smokers, while the verification setincluded 150 patients with lung nodules.

resultsCompared with the control group, the plasma expression level of miR-210 was significantly higher in the group of patients with benign pulmonary nodules (P < 0.05). The level of miR-486-5p was lower in patients with malignant pulmonary nodules compared to those with benign pulmonary nodules (P < 0.05). Moreover, the plasma level of miR-210was higher in patients with malignant pulmonary nodules compared to those with benign pulmonary nodules and healthy smokers (P < 0.05). The combination of miR-21 and miR-486 yielded an AUC of 0.865, which was significantly higher than any other gene combination (95%CI: 0.653-0.764, P < 0.05).

conclusionsThis study offered preliminary evidence supporting the use of peripheral blood miR-21 and miR-486, combined with CT scans, as potential biomarkers for the early cancer diagnosis in lung nodules.

Indexed as

Lung NeoplasmsMicroRNAsTomography, X-Ray ComputedAdultAgedBiomarkers, TumorEarly Detection of CancerFemaleHumansMaleMiddle AgedSolitary Pulmonary NoduleBiomarkers, TumorMicroRNAsMIRN21 microRNA, humanMIRN486 microRNA, humanEarly CT diagnosismiR-21 and miR-486Peripheral bloodPulmonary nodules

Identifiers

PMID39304898
PMCPMC11414282

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