Evidence map›Paper›PMID 39304897›Full record

ArticleTranslational neurodegeneration2024

GCN2 inhibition reduces mutant SOD1 clustering and toxicity and delays disease progression in an amyotrophic lateral sclerosis mouse model.

Didio Alberto Ortiz, Nuria Peregrín, Miguel Valencia, Rodrigo Vinueza-Gavilanes, Elisa Marín-Ordovas, Roberto Ferrero, María Jesús Nicolás, Gloria González-Aseguinolaza, Montserrat Arrasate, Tomás Aragón

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neurodegeneration, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. RNA triggers chronic stress during neuronal aging.bioRxiv : the preprint server for biology · 2025
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Didio Alberto Ortiz *DNA and RNA Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Nuria Peregrín *DNA and RNA Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Miguel ValenciaBiomedical Engineering Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Rodrigo Vinueza-GavilanesDNA and RNA Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Elisa Marín-OrdovasNeuroimmunology Department, Multiple Sclerosis Center of Catalonia (Cemcat), Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Roberto FerreroDNA and RNA Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
María Jesús NicolásBiomedical Engineering Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Gloria González-AseguinolazaDNA and RNA Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Montserrat Arrasate *DNA and RNA Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. MONTSERRAT.ARRASATEIRAGUI@bio-bizkaia.eus.
Tomás Aragón *DNA and RNA Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. taragon@unav.es.ORCID 0000-0002-1700-2729

Funding

Fundación para la Investigación Médica Aplicada AC Predoctoral FellowshipFundación para la Investigación Médica Aplicada Proyectos I+D, 2017Ministerio de Ciencia e Innovación, Gobierno de España BFU2017-90043-PMinisterio de Ciencia y Universidades, Gobierno de España PID2020-120497RB-I00Navarra Institute for Health Research (IdiSNA) Proyecto Intramural IdisNa 2022República de Panamá, Programa de Becas IFARHU-SENACYT 270-2018-922
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisDisease Models, AnimalDisease ProgressionMice, TransgenicSuperoxide Dismutase-1AnimalsHumansMiceMutationProtein Serine-Threonine KinasesProtein Serine-Threonine KinasesSod1 protein, mouseSuperoxide Dismutase-1

Identifiers

PMID39304897
PMCPMC11414287

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.