ReviewHealth and quality of life outcomes2024
Estimating the minimally important difference for the EQ-5D-5L and EORTC QLQ-C30 in cancer.
Review in Health and quality of life outcomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global evidence on the effectiveness of task-shifting and task-sharing strategies for managing individuals with multimorbidity: systematic review and meta-analysis.Family medicine and community health · 2025Pooled it
- Darolutamide Alone and in Combination With Goserelin in Androgen Receptor-Positive Salivary Gland Carcinoma: Results From the Phase II DISCOVARY Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026Trial
- Health-related quality of life in immunocompromised adults with mild-moderate COVID-19 treated with nirmatrelvir-ritonavir: results from the randomized, double-blinded EPIC-IC trial.Health and quality of life outcomes · 2026Trial
- Quality of life and care experience in durable responders to immune checkpoint inhibitors for advanced or metastatic NSCLC or melanoma.Immuno-oncology technology · 2026Article
- Early post-operative changes in quality of life and psychological symptoms after breast cancer surgery: the role of perceived pain, upper limb disability, and disease acceptance.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Age-stratified difference in patient-reported health-related quality of life following breast cancer surgery.Breast cancer research and treatment · 2026Article
- Assessing the impact of proton versus photon therapy on health-related quality of life in lung cancer.Clinical and translational radiation oncology · 2026Article
- Factors associated with health-related quality of life in survivors of childhood-onset and adult-onset cancer compared to controls.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Impact of unmet needs on health-related quality of life among cancer survivors in Ulsan, Korea.BMC cancer · 2026Article
- Locked-Window EQ-5D-5L (Index and VAS) Benchmarking in Sarcoma Care: Rule-Based Traffic-Light Classification Across Two Institutions.Diseases (Basel, Switzerland) · 2026Article
- Interpreting patient-reported outcomes after ischemic stroke: defining minimal important difference in EQ-5D across recovery phases.Health and quality of life outcomes · 2026Observational
- Translating the EORTC CAT core and the QLQ-C30 to the EQ-5D-5L in patients with metastatic breast cancer: A comparison of direct and indirect mapping algorithms.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Psychological and quality of life outcomes associated with multikinase inhibitors versus immune checkpoint inhibitors in advanced hepatocellular carcinoma.Scientific reports · 2026Article
- Is EQ-5D-5L sensitive enough to detect treatment-related changes in health status of prostate cancer patients? A nationwide Norwegian longitudinal study from the prostate cancer registry.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Unraveling assumptions about clinical relevance in patient-reported outcome data : A qualitative study on perspectives of different interest groups.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Multidisciplinary Palliative Care and Its Impact on Symptom Burden and Quality of Life in Advanced Cancer Patients in Ethiopia: A Pre-Post Quasi-Experimental Study.Cancer management and research · 2026Article
- Efficacy and Safety of Implantable Left Ventricular Assist Devices for Destination Therapy: A Peruvian Health Technology Assessment.Clinical Medicine Insights. Cardiology · 2026Article
- Association between psychological resilience and global health status/quality of life in patients with brain metastases after resection of primary non-small cell lung cancer.Frontiers in psychiatry · 2026Article
- Article
- A Dyadic Approach to Cancer Care: Examining the Feasibility and Preliminary Effectiveness of a Partner-Based Exercise Intervention for Caregivers and Their Care Recipients.International journal of environmental research and public health · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe minimal important difference (MID) is a useful tool to interpret changes in patients' health-related quality of life. This study aims to estimate MIDs for interpreting within-patient change for both components of the EQ-5D-5L questionnaire [EQ-Visual Analogue Scale (EQ-VAS) and utility index] and domains of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) for cancer patients.
methodsData were obtained from the Cancer 2015 dataset, a longitudinal cohort of Australian cancer patients. Anchor-based approaches were used to estimate MIDs for the EQ-5D-5L index-based utility index [Australia and the United States (US) tariff sets], EQ-VAS scores, and the EORTC QLQ-C30. Clinical [Eastern Cooperative Oncology Group (ECOG) performance status] and patient-reported (items 29 and 30 of the EORTC QLQ-C30 and the EQ-VAS) anchors were assessed for appropriateness by their correlation strength. Clinical change groups (CCGs) were defined a priori for improvement and deterioration based on estimates used in previous literature. MIDs were estimated via linear regression and distribution-based methods.
resultsFor the index-based utility scores in Australia, the anchor-defined MID estimates were 0.01 to 0.06 for improvement and - 0.04 to -0.03 for deterioration, with a weighted value of 0.03 for improvement and deterioration. The EQ-VAS MID estimate was 5 points for both improvement and deterioration. For the EORTC QLQ-C30, changes of at least 3.64 (improvement) and - 4.28 (deterioration) units on the physical functioning scale, 6.31 (improvement) and - 7.11 (deterioration) units on the role functioning scale, 4.65 (improvement) and - 3.41 (deterioration) units on the emotional functioning scale, and 5.41 (improvement) and - 5.56 (deterioration) units on the social functioning scale were estimated to be meaningful.
conclusionThis study identified lower MIDs for the EQ-5D-5L utility index, EQ-VAS, and EORTC QLQ-C30 domain scores, than those reported previously. The use of a real-world cancer-specific panel dataset may reflect smaller MID estimates that are more applicable to cancer patients in the clinical practice, rather than using MIDs that have been estimated from clinical trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.